低氧运动调控PPARα表达的研究述评

Review on the Regulation of PPARα Expression by Hypoxic Exercise

过氧化物酶体增殖物激活受体α(PPARα)是参与调控脂代谢、抑制炎症反应和促进脂肪细胞分化的重要细胞核受体。而低氧运动可通过激活一系列分子应答机制,促进机体不同组织PPARα表达及其介导的信号分子通路重新整合,从而改变机体脂代谢体系。利用文献资料法,梳理低氧刺激对机体PPARα表达影响的相关研究,总结不同组织PPARα对其低氧运动产生代偿性适应的可能分子机制,旨在更好地解释低氧环境下运动机体PPARα在调控脂代谢中的作用。

Peroxisome proliferator-activated receptor a （PPARa） is an important nuclear receptor involved in regulating lipid metabolism, inhibiting inflammatory reaction and promoting adipocyte differentiation. However, hypoxic exercise can promote the expression of PPARαin different tissues and reestablish the signal pathway through the activation of a series of molecular response mechanisms, thus altering the body lipid metabolism system. The aim of this study applies method of literature to comb the previous studies on the effect of hypoxia stimulation on the expression of PPARa, and summarize the possible molecular mechanism of compensatory adaptation of PPARα to hypoxic exercise in different tissues. The aim of this study is to better explain the effects of PPARαon the regulation of lipid metabolism in hypoxic environment.