香菇多糖的作用机制及临床应用进展

Mechanism and Clinical Application of Lentinan

香菇多糖是从真菌香菇的子实体中分离出的β-1,3-葡聚糖,是一种具有抑制肿瘤和提高免疫功能的多糖类生物反应调节剂,通过非特异性激发激活宿主产生抗肿瘤免疫应答,以达到控制和杀灭肿瘤细胞的目的。其主要用于辅助药物治疗、联合放化疗和改善预后等方面,目前国内外临床应用已显示出了较好的疗效。因此,深入了解香菇多糖的活性成分及其作用机制,可为肿瘤的诊治提供新思路,具有良好的临床应用前景。

Lentinan,a kind of β-1,3-polyglucosan,is isolated from fruiting body of lentinusedodes. It is pointed out that lentinan can enable host cells to generate antitumor immune response by stimulating and enhancing immunological function response,in this way the lentinan can control and kill tumor cells. It is mainly used in the ancillary drug therapy,combination of radiotherapy and chemotherapy and the improvement of prognosis,and the current clinical applications at home and abroad has shown good effect. Insights into the active ingredients of lentinan and its mechanisms of action can provide new ideas in cancer diagnosis and therapy,which has good clinical application prospects.