胆囊胆固醇结石的形成机制

The Mechanism of Gallbladder Cholesterol Stones Formation

胆囊胆固醇结石是临床上的一种常见病,其成因非常复杂。从机制上而言,其形成大致可以概括为胆汁胆固醇过饱和、胆固醇成核增加及胆囊排空障碍三个方面。其中,肝脏胆固醇分泌增加、胆汁胆固醇浓度过饱和致使胆汁中胆固醇结晶析出是胆固醇结石形成的关键步骤,而这一步骤的形成原因涉及饮食摄入不当、肠道吸收增加以及肝脏胆固醇代谢及调控异常等多个方面的多个基因。

Gallbladder cholesterol stones is a kind of common clinical disease,the etiology of which is very complicated. In general,the formation of gallbladder cholesterol stones is connected with supersaturation of bile cholesterol,increase of cholesterol nucleation and disorder of gallbladder emptying,of which,increase of liver cholesterol secretion and supersaturation of bile cholesterol are the key steps in the cholesterol gallstone formation. The reasons of this phenomenon include improper diet,intestinal absorption increase and genes associated with abnormal metabolism and regulation of liver cholesterol.