3种药物联合治疗小儿急性白血病的疗效观察及护理效果

The curative effect and nursing effect of 3 drugs combined treatment for children with acute leukemia

目的：探究贞芪扶正颗粒配合去甲氧柔红霉素联合阿糖胞苷化疗治疗小儿急性白血病的疗效及护理效果。方法以该院2013年4月至2016年4月入院的急性白血病患儿47例作为研究对象，随机分为研究组（23例）和对照组（24例）。其中对照组在接受化疗治疗期间只采用去甲氧柔红霉素＋阿糖胞苷方案规范诱导缓解治疗；研究组则辅以贞芪扶正颗粒进行辅助治疗。观察比较两组的临床疗效及化疗不良反应发生率。结果研究组和对照组患儿完全缓解率差异无统计学意义（P＞0．05）；研究组粒细胞最低值为（0．257±0．113）×109／L ，对照组粒细胞最低值为（0．101±0．094）×109／L ，研究组显著高于对照组，差异有统计学意义（P＜0．05）；研究组粒细胞缺乏持续时间显著短于对照组，差异有统计学意义（P＜0．05）。此外，研究组血小板缺乏持续时间显著低于对照组，差异有统计学意义（P＜0．05）。在患儿化疗期间感染情况比较重，研究组患儿感染发生率为78．3％，对照组为100．0％，两组差异有统计学意义（ P＜0．05）。结论贞芪扶正颗粒的使用可以有效控制去甲氧柔红霉素和阿糖胞苷化疗方案产生的毒副反应，且不影响去甲氧柔红霉素和阿糖胞苷化疗方案的疗效。

Objective To study the effect of Zhenqifuzheng granules on the clinical and nursing efficacy of Idarubucin‐Ara（IA） treatment for children with acute leukemia .Methods Totally 47 cases hospitalized and diagnosed with acute leukemia from April 2013 to April 2016 were taken into this research and randomly divided into the control group （n=24） and study group（n=23） .The control group were given the idarubicin and cytarabine in order to reach the remission ,while the study group was given both the Zhenqifuzheng granules and the same therapeutic schedule during the chemotherapy .The clinical efficacy of both groups were com‐pared after 2 courses and the adverse reactions were recorded during the treatment .Results There was no significant difference in complete remission rate between the study group and the control group （P〉 0 .05） .The lowest value of the study group was （0 .257 ± 0 .113） × 109/L ,the lowest value of the control group was （0 .101 ± 0 .094） × 109/L ,the study group was significantly higher than the control group（P〈0 .05） .In addition ,the duration of the study group was significantly lower than that of the control group （P〈0 .05） .During the period of chemotherapy ,the incidence of infection in children was more serious ,the incidence of infec‐tion in the study group was 78 .3% ,the control group was 100 .0% ,the difference was statistically significant （P〈0 .05） .Conclu‐sion Zhenqifuzheng granules can effectively control the toxic side effects caused by the chemotherapy regimen of erythromycin and erythromycin ,and does not affect the efficacy of IA chemotherapy regimen .