波罗蜜根酚性化学成分研究

Phenolic constituents from roots of Artocarpus heterophyllus

目的研究桑科植物波罗蜜Artocarpus heterophyllus根酚性化学成分。方法运用ODS、MCI CHP-20P、Sephadex LH-20等柱色谱和高效液相色谱技术从波罗蜜根中分离化合物,并根据理化性质和NMR、MS波谱数据鉴定化合物结构。结果从波罗蜜根95%乙醇提取物中分离得到17个酚性化合物,分别鉴定为1-O-阿魏酰甘油(1)、hypargystilbene A(2)、氧化白藜芦醇(3)、2′,3,4′,5,5′-五羟基-顺式-均二苯代乙烯(4)、白藜芦醇(5)、2,4-二羟基苯甲酸乙酯(6)、原儿茶酸乙酯(7)、伞形花内酯(8)、8-(3,3-二甲基烯丙基)-6,7-二羟基香豆素(9)、桑查耳酮A(10)、桂木二氢黄素(11)、styracifolin C(12)、柘树黄酮C(13)、异叶波罗蜜素(14)、环异叶波罗蜜素(15)、artonin A(16)和artonin B(17)。结论化合物9为首次从天然产物中分离得到,化合物1、4和6为首次从桑科植物中分离得到,化合物8为首次从波罗蜜属植物中分离得到,化合物3、5、10、11、14和15为首次从波罗蜜中分离得到。

Objective To investigate the phenolic constituents from the roots of Artocarpus heterophyllus. Methods Compounds were isolated from the roots of the plant by column chromatography over ODS, MCI GEL CHP-20P, Sephadex LH-20 and by preparative HPLC. Their structures were identified by the analysis of their physicochemical properties and the spectral data of NMR and MS. Results Seventeen phenolic compounds were isolated from the roots of the plant, namely 1-O-feruloylglycerol （1）, hypargystilbene A （2）, oxyresveratrol （3）, 2′,3,4′,5,5′-pentahydroxy-cis-stilbene （4）, resveratrol （5）, ethyl 2,4-dihydroxybenzoate （6）, ethyl 3,4-dihydroxybenzoate （7）, umbelliferone （8）, 8-（3,3-dimethylallyl）-6,7-dihydroxycoumarin （9）, morachalcone A （10）, artoearpanone （11）, styraeifolin C （12）, cudraflavone C （13）, heterophyllin （14）, cycloheterophyllin （15）, artonin A （16）, and artonin B （17）. Conclusion It is the first report of the occurrence of compound 9 as a natural product. Compounds 1, 4, and 6 are isolated from the plants of Moraceae family for the first time. Compound 8 is first obtained from the plants ofArtocarpus J. R. et G. Forst., while compounds 3, 5, 10, 11, 14, and 15 are first found in A. heterophyllus.