观察芪苈强心胶囊早期防治糖尿病伴射血分数保留心力衰竭的疗效

目的观察芪苈强心胶囊干预糖尿病伴早期射血分数保留心力衰竭(HFp EF)的临床疗效。方法选择成都市第六人民医院2014-02—2016-02收治的112例糖尿病伴早期HFpEF的患者,将其随机分为两组,其中对照组56例给予常规西药抗心衰治疗,观察组56例再加用芪苈强心胶囊。分别于治疗前、治疗12周时分析和比较两组的总有效率及早期二尖瓣最大血流速度(EV)、晚期二尖瓣最大血流速度(AV)、血管紧张素Ⅱ(AngⅡ)及醛固酮、明尼苏达评分(MLHFQ)及Lee氏评分等指标。结果治疗后两组比较,观察组总有效率高于对照组(91.1%比71.4%),且心衰早期(A、B期)有效率更高(95.1%比70.0%)(P<0.05);观察组患者的EV及LVEF较对照组有改善,AV、醛固酮、Lee氏评分及明尼苏达评分均较对照组降低,差异有统计学意义(P<0.05)。结论芪苈强心胶囊可改善糖尿病伴早期HFpEF患者的临床症状及其左室舒张功能。

Objective To observe the clinical effect of Qiliqiangxin capsules in the intervention of early heart failure with preserved ejection fraction（HFpEF） accompanied with diabetes.Methods A total of 112 sufferers with HFpEF accompanied with diabetes admitted to Chengdu No.6 Hospital from February 2014 to February 2016 were randomly divided into two groups.56 sufferers in the control group were treated with routine western medicine for anti-heart failure treatment,while 56 sufferers in the observation group were treated with additional Qiliqiangxin capsules.The total effective rate, EV, AV, Ang 11 , aldosterone level, MLHFQ score and Lee scale in both groups prior treatment and after 12 weeks of treatment were analyzed and compared. Results After treatment,the total effective rate of the observation group was higher than that of the control group with 91.1% and 71.4%, especially with a higher effective rate for early heart failure（stage A, B） with 95.1% and 70.0%（P〈0.05）.Compared with the control group, EV and LVEF in the observation group got improved,and AV,aldosterone level,Lee scale,and MLHFQ score in the observation group reduced, with differences of statistical significance（P〈0.05）.Conclusion Qiliqiangxin capsules can effectively improve the symptoms and left ventricular diastolic function of early heart failure with preserved ejection fraction（HFpEF） accompanied with diabetes.