左氧氟沙星注射液不良反应发生风险分析

Analysis of Risk of Adverse Reactions of Levofloxacin Injection

目的分析左氧氟沙星注射液不良反应发生风险,提高临床用药的合理性。方法选择2012年1月—2016年6月1 000例使用左氧氟沙星注射液患者作为该次研究观察对象,观察不良反应的发生率以及表现和特点,并采取相应的处理措施。结果 1 000例使用左氧氟沙星注射液的患者中,有50例出现不良反应,主要不良反应为皮疹、瘙痒、静脉炎,少数患者出现过敏反应、局部皮肤反应、消化系统反应、呼吸系统反应、精神系统反应。经对症处理后症状缓解。通过分析发现,不良反应的发生与患者的年龄、用药量与疗程、过敏史、合并用药等因素有关。结论临床中需要重视左氧氟沙星注射液的合理使用,医护人员需要加强对患者用药的监督,针对年龄大、用药量大且疗程长、过敏史多、联合用药的患者需要合理考量,能够减少不良反应的发生。

Objective To analyze the risks of adverse reactions of levofloxacin injection and improve the rationality of clinical medication. Methods 1 000 cases of patients with levofloxacin injection from January 2012 to June 2016 were selected as the observation objects, the incidence rate of adverse reactions and manifestations and features were observed, and the corresponding handling measures were adopted. Results In the 1 000 cases of patients with levofloxacin injection, adverse reactions occurred to 50 cases, and the main adverse reactions were rash, itching and phlebitis, and allergic reaction, local skin reaction, digestive system, respiratory system and mental system occurred to few patients, and the symptoms were relieved after the symptomatic treatment, and the analysis showed that the occurrence of adverse reactions was related to the age, dosage, curative effect, allergic history and concomitant medication. Conclusion In clinic, we need to pay attention to the rational use of levofloxacin injection, and the medical staff needs to enhance the supervision of medication of patients,and we need to rationally consider the senile patients with high dosage, long treatment course, more allergic histories and combined medication, thus reducing the occurrence of adverse reactions.