抗痤疮丙酸杆菌疗法治疗痤疮的研究进展

The Progress of Treating Acne by Anti-Propionibacterium Acnes

寻常痤疮是皮肤科最常见的疾病之一。炎症反应在痤疮病变中发挥着重要作用,而痤疮丙酸杆菌的感染常常与痤疮的炎症损害密切相关,因此抗菌疗法可作为痤疮的有效治疗方法。临床上针对痤疮丙酸杆菌的治疗方法有很多,包括系统服用四环素类、大环内酯类等抗生素,局部应用抗生素药膏,以及红蓝光、5-氨基酮戊酸光动力等物理疗法。现代药理研究证实,部分中草药同样也具有抗菌功效,且中药联合红蓝光治疗痤疮的有效性已在临床上得到证实。由于细菌耐药性的出现,红蓝光等物理疗法以及中医中药治疗越来越受到重视。

Acne vulgaris is one of the most common diseases in dermatology. Inflammatory reaction plays an important role in acne progress,and the infection of Propionibacterium acnes is often closely associated with acne inflammation damage,therefore,antibacterial therapy can be used as an effective treatment for acne. There are all kinds of treatment for acne aim at Propionibacterium acnes,including the system taking antibiotics such as tetracycline,macrolide,topical antibiotic ointment,and physical therapy such as the red and blue light,5-amino ketones pentanoic acid photodynamic. Modern pharmacological study has confirmed that some Chinese herbal medicines also have effection of sterilization,and the effectiveness of combination therapy of Chinese herbal medicine plus red and blue light has been confirmed clinically. Due to the emergence of bacterial resistance,the physical therapy such as red and blue light and Chinese herbal medicine have drawing more and more attention now.