Vaspin改善2型糖尿病大鼠胰岛素抵抗被引量：6

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摘要胰岛素抵抗（insulin resistance,IR）是2型糖尿病（type 2diabetes mellitus,T2DM）的主要发病机制之一。内脏脂肪特异性丝氨酸蛋白酶抑制剂（visceral adipose tissue-derived serpin,Vaspin）是从OLETF大鼠内脏脂肪组织中分离出来的一种具有胰岛素增敏效应的脂肪细胞因子[1]。但是目前关于Vaspin改善IR的机制尚不完全清楚。

作者刘师伟王明明杜芳李欣张丽王军姜茜申竹芳

机构地区山西医科大学附属大医院内分泌科山西医科大学研究生学院中国医学科学院北京协和医学院药物研究所天然药物活性物质与功能国家重点实验室

出处《基础医学与临床》 CSCD 2016年第11期1560-1562,共3页 Basic and Clinical Medicine

基金国家自然科学基金(81200591 81471025) 山西省留学回国人员科技活动择优资助项目(2013-251) 山西省回国留学人员科研资助项目(2015-109) 山西省国际科技合作计划项目(2015081029)

关键词胰岛素抵抗 VASPIN 内脏脂肪组织糖尿病大鼠脂肪细胞因子主要发病机制胰岛素增敏正常葡萄糖 VISCERAL ADIPOSE

分类号 R587.1 [医药卫生—内分泌]

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1刘师伟,王明明,王军,楼晓华,董艳婷,张丽,赵术君,何玉洁.Vaspin对HUVECs中TNF-α介导的NF-κB和PI3K/Akt信号通路的影响[J].基础医学与临床,2015,35(8):1020-1024. 被引量：6

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