摘要
microRNA(miRNA)是一类长度约为22 nt的内源性非编码RNA,其表达异常可能导致炎性反应失衡。在脓毒症期间,miR-146a、miR-223和miR-150表达水平降低,而miR-15a和miR-16表达增高。脓毒症患者外周血中miRNA表达水平的异常与患者病情密切相关,因此,miRNA能否作为脓毒症早期诊断的生物标志物备受关注,并已初步取得可喜成果。
microRNAs are endogenous non-coding RNA molecules consists of about 22 nucleotides that play a key role in posttranslational gene silencing. Circulation miRNA,such as miR-146 a,miR-223,miR-150,miR-15 and miR-16,play important roles in the evaluation of septic patients＇ status. In this article,we summarize the recent progress on the circulating miRNA as biomarkers for the diagnosis of sepsis and how miRNAs regulate the inflammatory responses in sepsis.
出处
《基础医学与临床》
CSCD
2016年第11期1591-1595,共5页
Basic and Clinical Medicine
基金
国家自然科学基金(81272149
81471901)
