长效β_2受体激动剂的研究进展

Recent advances in study of long β_2-adrenoceptor agonist

β_2受体激动剂作为支气管扩张药物广泛用于治疗慢性阻塞性肺部疾病(COPD)和哮喘。在过去的15年中,制药行业对于开发新的可用于单一疗法或组合疗法的长效β_2受体激动剂表现出极大的兴趣。因此,寻找用于治疗COPD和哮喘的长效β_2受体激动剂也成为新药研发的一个重点。本文主要介绍长效β_2受体激动剂的作用机制、优秀的候选化合物等最新研究进展。

β2-Adrenoceptor agonists are highly effective bronchodilators and are widely used in the treatment of both chronic obstructive pulmonary disease（COPD） and asthma. In the last 15 years, there has been great interest within the pharmaceutical industry in the discovery of a long β2-adrenoceptor agonist for a mono-therapy or combination therapy. The search for new long-acting β2-adrenoreceptor agonists（LABA＇s）, for the treatment of asthma and COPD, has become a very active area of drug discovery. This article reviews the mechanisms, potential candidates and research advances of long β2-adrenoceptor agonists.