冠心病患者血清炎性因子、黏附分子含量及其对病变程度判断价值的研究

Serum inflammatory cytokine and adhesion molecule content in patients with coronary heart disease and their value for disease severity diagnosis

目的:分析冠心病患者血清炎性因子、黏附分子含量检测及其对病变严重程度的判断价值。方法:113例冠心病患者及107例健康人被纳入研究,根据冠心病病情严重程度进一步将冠心病组患者分为轻度组患者40例,中度组患者52例,重度组患者21例。检测所有入组患者的血清炎性因子及黏附分子含量,进一步分析炎性因子、黏附分子含量在判断冠心病病变严重程度方面的价值。结果:冠心病组血清C-反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、几丁质酶-3样蛋白1(YKL-40)水平高于健康对照组,白介素-35(IL-35)水平低于健康对照组(P<0.05);冠心病组血清E-选择素(E-selectin)、单核细胞黏附分子(ICAM-1)、血管细胞黏附分子-1(VCAM-1)、可溶性细胞间黏附分子(sICAM-1)水平均高于健康对照组(P<0.05);轻度组血清CRP、TNF-α、YKL-40、E-selectin、ICAM-1、VCAM-1、sICAM-1水平低于中度组及重度组,IL-35水平高于中度组及重度组(P<0.05),且随着冠心病病情加重CRP、TNF-α、YKL-40、E-selectin、ICAM-1、VCAM-1、sICAM-1水平上升,IL-35水平下降(P<0.05)。结论:冠心病患者血清炎性因子、黏附分子含量发生显著改变,与冠心病严重程度具有直接相关关系,可以作为评估冠心病患者病情及预后的可靠手段。

Objective： To detect inflammatory cytokine and adhesion molecule content in patients with coronary heart disease and analyze their value for disease severity diagnosis. Methods.. A total of 113 patients with coronary heart disease and 107 healthy subjects were included in the study and further divided into mild group （n = 40）, moderate group （n = 52） and se- vere group （n = 21） according to the severity of coronary heart disease. Serum inflammatory cytokine and adhesion molecule content of all subjects were detected, and the value of inflammatory cytokine and adhesion molecule content for judging the se- verity of coronary heart disease was further analyzed. Results： Serum CRP, TNF-α and YKL-40 levels of coronary heart disease group were higher than those of healthy control group while IL-35 level was lower than that of healthy control group （P〈 0.05） ;serum E-selectin, ICAM-1, VCAM-1 and sICAM-1 levels of coronary heart disease group were higher than those of healthy control group （P〈0.05）; serum CRP, TNF-α, YKL-40, E-selectin, ICAM-1, VCAM-1 and sICAM-1 levels of mild group were lower than those of moderate group and severe group, IL-35 level was higher than those of moderate group and se-vere group （P 〈0.05）, and with the aggravation of coronary heart disease, CRP, TNF-α, YKL-40, E-seleetin, ICAM-1, VCAM-1 and sICAM-1 levels increased while IL-35 level decreased （P〈0.05）. Conclusion：= Serum inflammatory cytokine and adhesion molecule content change significantly in patients with coronary heart disease, are directly correlated with the severity of coronary heart disease and can be used as the reliable means to assess the condition and prognosis of patients with coronary heart disease.