茶碱控释片联合β2受体激动剂治疗支气管哮喘的气道功能及炎症程度评价

Evaluation of airway function and inflammation after theophylline controlled release tablet combined withβ2 receptor agonist treatment of bronchial asthma

目的:研究茶碱控释片联合β2受体激动剂治疗对支气管哮喘患者气道功能及炎症程度的影响。方法:选择我院收治的112例支气管哮喘患者作为研究对象,随机分为两组,观察组接受糖皮质激素抑炎、茶碱控释片联合β2受体激动剂舒张气道,对照组接受糖皮质激素抑炎、β2受体激动剂舒张气道。治疗后8周时,测定气道功能、血清中信号通路分子及细胞因子含量、外周血中免疫细胞含量。结果:治疗后8周时,观察组的潮气量(VT)、用力呼气容积(FEV1)、最大呼气峰流速(PEF)水平均显著高于对照组,呼出气一氧化氮(FeNO)含量均显著低于对照组;观察组血清中Toll样受体(TLR2)、连接蛋白髓样分化蛋白88(MyD88)、c-Jun氨基末端激酶(JNK)、白细胞介素-4(IL-4)、白细胞介素-5(IL-5)的含量均显著低于对照组,干扰素-γ(IFN-γ)、白细胞介素-2(IL-2)、白细胞介素-10(IL-10)、转化生长因子-β(TGF-β)的含量显著高于对照组;观察组外周血中CD4^+IFNγ^+Th1细胞、CD4^+CD25^+Foxp3^+Treg细胞的含量显著高于对照组,CD4^+IL-4^+Th2细胞的含量显著低于对照组。结论:茶碱控释片联合β2受体激动剂治疗能够改善支气管哮喘患者的气道功能、减轻TLR2所介导的炎症反应及T淋巴细胞亚群功能紊乱。

Objective： To study the effect of theophylline controlled release tablet combined with 132 receptor agonist therapy on airway function and inflammation in patients with bronchial asthma. Methods.. A total of 112 patients with bronchial asthma treated in our hospital were selected as the research subjects and randomly divided into two groups： observation group received corticosteroid for anti-inflammation and theophylline controlled release tablet combined with 132 receptor agonist for airway dilation, and control group received glucocorticoid for anti-inflammation and 132 receptor agonist for airway dilation. Af- ter 8 weeks of treatment, airway function, signal pathway molecule and cytokine content in serum as well as immune cell con- tent in peripheral blood were determined. Results： After 8 weeks of treatment, VT, FEVI and PEF levels of observation group were significantly higher than those of control group while FeNO content was significantly lower than that of control groups se-rum TLR2, MyD88, JNK, IL-4 and IL-5 content of observation group were significantly lower than those of control group while IFN-γ, IL-2, IL-10 and TGF-13 content were significantly higher than those of control group; CD4＋ IFNγ＋ Th1 cell and CD4＋ CD25＋ Foxp3＋ Treg cell content in peripheral blood of observation group were significantly higher than those of control group while CD4＋ IL-4＋ Th2 cell content was significantly lower than that of control group. Conclusion： Theophylline controlled release tablet combined with 132 receptor agonist therapy can improve the airway function in patients with bronchial asthma and reduce the TLR2-mediated inflammation as well as T lymphocyte subset dysfunction.