甲磺酸加贝酯与乌司他丁联合治疗对胰腺炎患者免疫功能、血液流变学和肠粘膜功能的影响

Influences of Gabexate Mesylate and Ulinastatin combined therapy on immune function,hemorheology and intestinal mucosal function of pancreatitic patients

目的:探究甲磺酸加贝酯与乌司他丁联合治疗对急性胰腺炎患者免疫功能、血液流变学和肠粘膜功能的影响,为急性胰腺炎患者的临床治疗提供帮助。方法:选取我院收治的170例急性胰腺炎患者,随机分为联合治疗组和对照组,每组各85例,对照组采用常规治疗同时应用乌司他丁,联合治疗组在常规治疗基础上给予甲磺酸加贝酯与乌司他丁治疗。治疗前后检测并分析各组免疫细胞、肠粘膜功能、炎症因子和血液流变学相关指标。结果:与治疗前相比,两组经治疗后血液流变学指标(BVH、PV、TL以及PAdT)、CD8^+、肠粘膜功能(D-乳酸、DAO、内毒素和L/M值)、炎症因子(CRP、TNF-α、IL-6)显著降低,免疫细胞(CD3^+、CD4^+和CD4^+/CD8^+)显著升高,差异存在统计学意义(P<0.05);与治疗后对照组相比,治疗后的联合治疗组血液流变学指标(BVH、PV、TL和PAdT)、CD8^+、肠粘膜功能(D-乳酸、DAO、内毒素和L/M值)、炎症因子(CRP、TNF-α、IL-6)显著降低,免疫细胞(CD3^+、CD4^+和CD4^+/CD8^+)显著升高,组间差异存在统计学意义(P<0.05)。结论:甲磺酸加贝酯联合乌司他丁能够显著改善急性胰腺炎患者免疫细胞、肠粘膜功能、炎症因子和血液流变学相关指标,对急性胰腺炎患者的治疗具有十分重要的临床意义。

Objective： To discuss the influences of Gabexate Mesylate and Ulinastatin combined therapy on immune function, hemorheology and intestinal mucosal function of patients with acute pancreatitis, and offer help to the clinical therapy for these patients. Methods： A total of 170 patients with acute pancreatitis treated in our hospital were selected and divided into combined therapy group and control group based on table of random digit. 85 cases were set for each group. For patients in con-trol group, conventional therapy was adopted, and Ulinastatin was added to the therapy. For patients in combined therapy group, Gabexate Mesylate and Ulinastatin were given on the basis of conventional therapy. Immune cells, intestinal mucosal function, inflammatory factors and relevant indexes of hemorheology on two groups of patients were detected and analyzed be- fore and after therapy. Results.. Hemorheological indexes （BVH, PV, TL and PAdT）, CD8＋ , intestinal mucosal function （D- Lactic acid, DAO, endotoxin and L/M value）, inflammatory factors （CRP, TNF-α, IL-6） on the two groups of patients were significantly increased after therapy compared with that before therapy, the differences showed statistical significance （P 〈0.05）.Hemorheological indexes （BVH, PV, TL and PAdT）, CD8＋ , intestinal mucosal function （D-Lactic acid, DAO, endo- toxin and L/M value）, inflammatory factors （CRP, TNF-α, IL-6） in combined therapy group were significantly decreased when compared with the control group after therapy, and immune ceils （CD3＋ , CD4＋ and CD4＋/CD8＋ ） were significantly in- creased, the differences showed statistical significance （P〈0.05）.Conclusion： Gahexate Mesylate and Ulinastatin combined therapy could significantly improve immune cells, intestinal mucosal function, inflammatory factors and hemorheology relevant indexes for patients with acute pancreatitis. It is of vital clinical significance for the therapy of patients with acute pancreatitis.