艾司西酞普兰和唑吡坦联用对老年慢性失眠患者睡眠结构、睡眠进程、神经递质的影响

Effect of Escitalopram combined with zolpidem on sleep structure,sleep process and neurotransmitter in elderly patients with chronic insomnia

目的:分析艾司西酞普兰和唑吡坦联用对老年慢性失眠患者睡眠结构、睡眠进程、神经递质的影响。方法:112例本院收治的老年慢性失眠患者纳入本次研究并随机分为观察组及对照组各56例。对照组接受单纯唑吡坦治疗,观察组接受艾司西酞普兰联合唑吡坦治疗,对比两组睡眠结构及睡眠进程、神经递质、应激激素、下丘脑-垂体-甲状腺轴指标等差异。结果:观察组治疗后睡眠结构、睡眠进程参数SL、RL、S2水平显著低于对照组,TST、S3、REM水平显著高于对照组;血清Orexin、ACTH、5-HT、NE、CRH、E、AngⅡ、Cor、ALD、DA、TGA含量均显著低于对照组,T3、T4、TSH、TRH含量均显著高于对照组。结论:艾司西酞普兰和唑吡坦联用可优化老年慢性失眠患者睡眠结构及睡眠进程,在调节机体内环境稳定方面也有突出作用。

Objective： To analyze the effects of Escitalopram combined with zolpidem on sleep structure, sleep process and neurotransmitter in elderly patients with chronic insomnia. Methods： A total of 112 elderly patients with chronic insomnia treated in our hospital were included in the study and randomly divided into observation group and control group （n = 56）. Con- trol group received zolpidem therapy alone, observation group received Escitalopram combined with zolpidem therapy, and then differences in sleep structure and process, neurotransmitter, stress hormones, hypothalamus-pituitary-thyroid axis indexes and so on were compared between two groups of patients. Results： The sleep structure and sleep process parameters SL, RL and S2 levels of observation group after treatment were significantly lower than those of control group while TST, S3 and REM levels were significantly higher than those of control group; Orexin, ACTH, 5-HT, NE, CRH, E, Ang Ⅱ , Cor, ALD, DA and TGA content in serum were significantly lower than those of control group while T3, T4, TSH and TRH content were signifi- cantly higher than those of control group. Conclusion： Escitalopram combined with zolpidem can optimize the sleep structure and process in elderly patients with chronic insomnia, and also plays a prominent role in regulating the body＇s homeostasis.