阿托伐他汀联合活血通脉胶囊治疗缺血性脑卒的机制研究

Mechanism of treating ischemic stroke by atorvastatin combined with Huoxuetongmai capsules

目的:探究阿托伐他汀联合活血通脉胶囊治疗缺血性脑卒的机制,为缺血性脑卒的临床治疗提供帮助。方法:选取我院收治的160例缺血性脑卒患者,随机分为观察组和对照组,每组各80例,对照组给予常规治疗,观察组在常规治疗的基础上给予阿托伐他汀和活血通脉胶囊的治疗,治疗前和治疗后检测缺血性脑卒患者血液流变学指标、炎症因子、凝血功能相关指标的变化情况。结果:两组缺血性脑卒患者治疗前血液流变学指标、炎症因子、凝血功能相关指标比较,差异无统计学意义(P>0.05);与治疗前相比,观察组经过阿托伐他汀联合活血通脉胶囊治疗后血液流变学指标全血高切黏度、全血低切黏度、血浆黏度、红细胞最大聚集指数、血细胞比容显著降低,凝血功能指标FIB、DDI、TXB2、PAI-1显著降低、PT显著升高,血清炎症因子IL-6、IL-8、CRP、TNF-α显著降低,比较差异存在统计学意义(P<0.05);与治疗后对照组相比,观察组经过联合治疗后血液流变学相关指标均显著降低,凝血功能指标FIB、DDI、TXB2、PAI-1显著降低、PT显著升高,血清炎症因子均显著降低,组间差异存在统计学意义(P<0.05)。结论:阿托伐他汀联合活血通脉胶囊的治疗能够改善缺血性脑卒患者血液流变学、炎症因子以及凝血功能,为缺血性脑卒患者的临床治疗提供帮助。

Objective： To investigate the mechanism of treating ischemic stroke by atorvastatin combined with Huoxue- tongmai capsules, for helping clinical treatment of ischemic stroke. Methods： A total of 160 patients with ischemic stroke were selected, and randomly divided into observation group and control group, each group was 80 cases, control group was given conventional treatment, and observation group was given atorvastatin combined with Huoxuetongmai capsules based on the a- bove conventional treatment, the changes of hemodynamic indexes, inflammation factors and coagulation function related inde- xes in patients with ischemic stroke were detected before and after treatment. Results： The comparison of hemodynamic inde- xes, inflammation factors and coagulation function related indexes in the two groups before treatment was not statistically sig- nificant （P〉0.05）. Compared with before treatment, hemodynamic indexes （whole blood high shear viscosity, whole blood low shear viscosity, plasma viscosity, maximum red blood cell aggregation index and hematocrit） and inflammation factors（IL-6, IL-8, CRP and TNF-α） in observation group after treatment by atorvastatin combined with Huoxuetongmai capsules significantly decreased, while coagulation function related indexes （FIB, DDI, TXB2 and PAI-1） significantly increased, and were considered to be statistically significant （P〈0.05）. Compared with control group after treatment, hemodynamic indexes, coagulation function related indexes （FIB, DDI, TXB2 and PAI-1） and inflammation factor in observation group after combined treatment significantly decreased, while PT significantly increased, there were statistically significant difference between the groups （P〈0.05）. Conclusion：The treatment of ischemic stroke by atorvastatin combined with Huoxuetongmai capsules could improve hemodynamic indexes, inflammation factors and coagulation function related indexes in patients with ischemic stroke, and provide help for clinical treatment of ischemic stroke.