醒脑静联合门冬氨酸鸟氨酸治疗对肝性脑病患者认知功能的影响

Influence of refreshing static combined with nmda ornithine for cognitive function of patients with hepatic encephalopathy

目的探讨醒脑静联合门冬氨酸鸟氨酸治疗对肝性脑病患者认知功能的影响。、方法回顾性分析2015年10月～2016年4月期间我院确诊治疗的肝性脑病患者50例，依据治疗方法分为门冬氨酸组和联合治疗组，每组25例，门冬氨酸组患者给予门冬氨酸鸟氨酸静脉滴注治疗，联合治疗组患者在此基础上给予醒脑静静脉滴注治疗，采用简易智力量表（MMSE）评价认知功能，采用长谷川痴呆量表（HDS）评价痴呆程度，统计分析所有患者的临床疗效、治疗前后认知功能和痴呆程度情况。结果联合治疗组患者治疗有效率明显高于门冬氨酸组（P〈0．05）；治疗前，门冬氨酸组和联合治疗组患者MMSE和HDS得分基本相同（P〉0．05），治疗后，联合治疗组患者MMSE和HDS得分明显高于门冬氨酸组（P〈0．05）。结论醒脑静联合门冬氨酸鸟氨酸治疗可有效提高肝性脑病患者的临床疗效，且具有保护神经功能和改善认知功能的作用。

Objective To discuss the influrence of c refreshing static combined with nmda ornithine for cognitive function of patients with hepatic encephalopathy. Methods 50 patients with hepatic encephalopathy cured in our hospital from October 2015 to April 2016 were retrospective analyzed. According to the treatment, all patients were divided into nmda group and joint group with 25 cases in each. Patients in nmda group were treated with nmda ornithine intravenous drip treatment, on this base, patients in joint group were treated with refreshing static injection intravenous drip treatment. Simple intelligence scale （MMSE） was used to evaluate the cognitive function. Hasegawa dementia scale （HDS） was used to evaluate the degree of dementia. Clinical efficacy, cognitive function and dementia degree before and after the treatment of all the patients were statisticaly analyzed. Results Efficient of joint group was higher than that of nmda group （P〈0.05）. Before the treatment, MMSE score and HDS of nmda group and joint group were almost the same （P〉0.05）. After treatment, MMSE and HDS score of joint group were higher than those of nmda group （P 〈 0.05）. Conclusion Refreshing static combined with nmda ornithine treatment can effectively improve the clinical curative effect of patients with hepatic encephalopathy, and it can protective effect of neural function and improve cognitive function.