HIV/AIDS患者CD4^+ T淋巴细胞检测结果与抗病毒治疗效果

Detection Results of CD4^+ T Lymphocytes and Antiviral Treatment Effects in Patients with HIV/AIDS in A Certain Area

目的探讨某地区HIV/AIDS患者CD4^+ T淋巴细胞检测结果与抗病毒治疗效果,同时进行相关性分析。方法2013年2月~2016年1月选择在笔者医院诊治的HIV/AIDS患者60例作为观察组,同期选择在笔者医院进行健康体检的健康人60例作为对照组,观察组都给予HAART标准治疗方案,观察组在治疗前后、对照组在入院时都进行CD4^+ T淋巴细胞与细胞因子表达的检测。结果观察组外周血的CD4^+CD45RA^+、CD4^+CD28^+、CD4^+CD45RO^+的细胞比例明显低于对照组(P<0.05),两组CD4^+CD25^+的细胞比例对比,差异无统计学意义(P>0.05)。与对照组相比,观察组的血浆IL-10和TGF-β1含量都显著升高(P<0.05)。治疗后观察组的CD4^+CD45RA^+、CD4^+CD28^+、CD4^+CD45RO^+的细胞比例都明显上升(P<0.05),而血浆IL-10和TGF-β1含量明显降低(P<0.05)。在观察组中,Spearman秩相关分析显示CD4^+CD45RA^+、CD4^+CD28^+、CD4^+CD45RO^+的细胞比例与IL-10、TGF-β1水平均呈负相关(P<0.05)。结论 HIV/AIDS患者只有较低的免疫功能,具有较低的CD4^+ T淋巴细胞亚群比例和较高的IL-10和TGF-β1水平,HAART治疗能改善免疫功能,为此通过CD4^+ T淋巴细胞就能判断HIV/AIDS患者的治疗效果和病情。

Objective To study the detection results of CD4＋ T lymphocytes and antiviral treatment effects in patients with HIV/ AIDS in a certain area. Methods From February 2013 to January 2016, 60 cases of HIV / AIDS patients in our hospital were selected as the observation group, 60 cases of healthy health people were selected at the same period in our hospital as the control group. The ob- servation group were given HAART standard therapy. The CD4＋ T lymphocytes and cytokines expression were detected in the observation group before and after treatment, and the control group at the time of admission were also give detected. Results The peripheral blood CD4 ＋ CD45RA＋ , CD4 ＋ CD28＋ , CD4 ＋ CD45RO＋ cell ratios in the observation group were significantly lower than the control group （ P 〈 0.05） , the CD4 ＋ CD25 ＋ cells ratios compared between the two groups had no statistically significant difference （P 〉 0.05 ）. Compared with the control group, the plasma IL - 10 and TGF - 131 contents in the observation group were significantly increased （P 〈 0.05 ）. After treatment, the CD4＋ CD45RA＋ , CD4＋ CD28 ＋ , CD4＋ CD45RO ＋ cell ratios were increased significantly in the observation group （P 〈 0.05 ） , and plasma IL - 10 and TGF - [31 contents were significantly reduced （P 〈 0.05 ）. In the observation group, Spearman rank cor- relation analysis showed that the CD4＋ CD45RA＋ , CD4＋ CD28＋ , CD4 ＋ CD45RO＋ cell ratios were showed obvious negative correlated to the IL - 10 and TGF -β1 level （P 〈 0.05 ）. Conclusion HIV / AIDS patients are more immunoeompromised that the CD4＋ T lympho- cyte cell ratios are increased and the IL - 10 and TGF -β1 levels were decreased and HAART can improve immune function, so the CD4＋ T lymphocytes can sensitively reflect the HIV / AIDS patients with the disease progression and treatment.