摘要
报道了丙硫菌唑中间体2-(2-氯苄基)-2-(1-氯环丙基)环氧乙烷的合成方法。以1-氯-N,N-二甲基环丙基甲酰胺和邻氯氯苄为原料,经格氏反应制备2-氯苄基-(1-氯环丙基)酮;后者再与硫叶立德试剂反应得到相应的环氧化物。
An improved method fo r synthesis of 2-(2-chloro-benzyl)-2-(1-chloro-cyclopropyl)oxirane,an important intermediate for producing prothioconazole,was studied.Thus,1-chloro-N,N-dimethylcyclopropanecarboxamide and2-chlorobenzyl chloride were subjected to a Grignard reaction to prepare 2-chlorobenzyl-(1-chloro-cyclopropyl)ketone,which was further reacted with sulfur ylide to give the corresponding oxirane.
出处
《现代农药》
CAS
2016年第6期31-32,37,共3页
MODERN AGROCHEMICALS