香砂枳术颗粒对脾胃虚弱证功能性消化不良患者的治疗作用

Clinical Efficacy of Xiangsha Zhizhu Granules for Functional Dyspepsia with Spleen and Stomach Deficiency

目的:通过观察香砂枳术颗粒对脾胃虚弱证功能性消化不良(FD)患者的胃肠激素、胃半排空时间、症状评分等临床指标的影响,考察其治疗作用。方法:将120例脾胃虚弱证功能性消化不良患者随机分为2组,治疗组60例,采用香砂枳术颗粒治疗,对照组60例,采用多潘立酮治疗,疗程均为2周,评价两组患者胃肠激素(乙酰胆碱酯酶,胃动素)、症状评分等指标,观察两组治疗效果,并比较两组疗效的差异。结果:治疗后两组脾胃虚弱证FD患者乙酰胆碱酯酶及胃动素水平均有明显改善(P<0.05),且治疗组乙酰胆碱酯酶、胃动素明显高于对照组(P<0.05);两组胃排空时间与治疗前比较均明显缩短(P<0.05);治疗后两组症状指标评分均有所下降(P<0.05),个别指标中治疗组较对照组具有更好的效果(P<0.05);两组均有明显的治疗效果,治疗组有效率明显优于对照组(P<0.05)。结论:香砂枳术颗粒对脾胃虚弱证FD患者临床症状有明显疗效,机制可能与其调节胃肠道激素增强FD患者胃动力有关,可在临床治疗中推广使用。

Objective： To observe the effects of Xiangsha Zhizhu granules on the clinical symptoms of gastrointestinal hormones, gastric emptying time, and symptom scores of patients with spleen and stomach deficiency type functional dyspepsia（ FD）,and explore its therapeutic effect. Method： The 120 FD patients with spleen and stomach deficiency were randomly divided into two groups： treatment group（ 60 cases） and control group（ 60 cases）. Patients in treatment group received Xiangsha Zhizhu granules treatment,and patients in control group received domperidone treatment,with a treatment course of 2 weeks for both groups. The indicators of gastrointestinal hormone（ acetylcholinesterase and motilin） and symptom scores were evaluated to observe the therapeutic effect of two groups and compare the difference between two groups. Result： The levels of acetylcholinesterase and motilin were significantly improved in two groups of FD patients after treatment（ P 〈 0. 05）,and the levels in treatment group was significantly higher than those in control group（ P 〈 0. 05）,the gastric emptying time was significantly shortened in both groups after treatment（ P 〈 0. 05）,the symptom index scores were decreased in both groups after treatment（ P 〈 0. 05）,and some indexes in treatment group achieved better effect than those in control group（ P 〈 0. 05）,the overall efficacy was obvious in both groups,and the efficacy of the treatment group was significantly better than that of control group（ P 〈 0. 05）. Conclusion：Xiangsha Zhizhu granules have obvious effect on the clinical symptoms of patients with spleen and stomach deficiency type FD,and the mechanism may be associated with promoting stomach power of FD patients by regulating gastrointestinal hormone,so it can be used widely in clinical treatment.