参芪扶正注射液对50例肺癌患者炎症反应因子的影响

Effect of Shenqi Fuzheng injection on inflammatory response factor in the treatment of 50 patients with lung cancer

目的 :观察和评估参芪扶正注射液对肺癌患者炎症反应因子的影响。方法 :随机选取肺癌患者100例,按照治疗的方式的不同分为观察组和对照组各50例。对照组采用单纯化疗治疗,观察组在对照组的基础上加用参芪扶正注射液治疗,采用ELISA检测血清因子,对比分析两组患者治疗疗效、血清炎症因子水平的变化及不良反应发生情况。结果 :观察组治疗有效率明显高于对照组(78.0%vs 56.0%)(P<0.05);两组患者治疗后TNF-α、IL-6、IL-8和IL-10水平明显低于治疗前且观察组明显低于对照组(P<0.01);观察组和对照组不良反应发生率基本相同。结论 :参芪扶正注射液能有效减轻患者的炎症反应,改善患者的免疫功能,且不增加患者不良反应发生的风险,有利于增强疗效。

Objective： To observe the effect of Shenqi Fuzheng injection on inflammatory response factor in the treatment of patients with lung cancer. Methods： One hundred patients with lung cancer were divided into an observation group and a control group with 50 cases each according to different treatment methods. The control group underwent chemotherapy alone while the observation group was given Shenqi Fuzheng injection in addition. Serum inflammatory factors were detected by ELISA. Clinical effect, serum inflammatory factor level and the incidence of adverse reactions were compared. Results： Effective rates for the treatment were higher in the observation group than in the control group（78.0% vs 56.0%）（P〈0.05）. The levels of TNF-α, IL-6, IL-8 and IL-10 were obviously lower in both groups after treatment than before and in the observation group than in the control group（P〈0.01）. The incidence of adverse reactions in both groups was basically same. Conclusion： Shenqi Fuzheng injection can effectively reduce the inflammatory reaction of the patients, improve the immune function of the patients, and not increase the risk of adverse reactions occurred in the patients, and is helpful to enhance the efficacy.