盐酸川芎嗪联合补阳还五汤治疗急性脑梗死及对患者血液黏度及凝血因子的影响

Ligustrazine Hydrochloride Injection Combined with Buyang Huanwu Decoction in Treatment of Acute Cerebral Infarction and Its Intervention on Blood Viscosity and Coagulation Factor

目的:探讨盐酸川芎嗪注射液联合补阳还五汤治疗急性脑梗死的疗效及对患者血液黏度及凝血因子的影响。方法:110例急性脑梗死患者随机分成两组,各55例。对照组:接受急性脑梗死常规治疗。观察组:接受急性脑梗死常规治疗,同时联合盐酸川芎嗪注射液及补阳还五汤治疗。比较两组患者的疗效、NHISS评分、血液黏度指标及凝血因子水平。结果:观察组总有效率92.7%高于对照组总有效率78.2%,差异具有统计学意义(P<0.05)。治疗后,观察组NHISS评分(9.10±2.23)分低于对照组NHISS评分(13.09±3.57)分,差异具有统计学意义(P<0.01)。治疗后,观察组全血低切黏度(8.12±3.26)m Pa·s、全血高切黏度(4.12±1.18)m Pa·s、血浆黏度(1.22±0.35)m Pa·s都低于对照组全血低切黏度(11.33±3.71)m Pa·s、全血高切黏度(6.09±1.22)m Pa·s、血浆黏度(2.08±0.54)m Pa·s,差异均有统计学意义(P<0.01)。治疗后,观察组凝血酶原时间(13.63±4.28)s、部分凝血活酶时间(30.61±8.02)s、凝血酶时间(23.26±6.09)s都高于对照组凝血酶原时间(10.55±3.46)s、部分凝血活酶时间(23.29±7.17)s、凝血酶时间(18.05±4.68)s差异均有统计学意义(P<0.01)。治疗后,观察组纤维蛋白原水平(2.69±0.33)g/L低于对照组纤维蛋白原水平(4.14±0.43)g/L,差异具有统计学意义(P<0.01)。结论:盐酸川芎嗪注射液联合补阳还五汤治疗急性脑梗死疗效显著,可以改善患者血液黏度及凝血因子。

Objective：To investigate the effect of Ligustrazine Hydrochloride Injection combined Buyang Huanwu Decoction in treatment of acute cerebral infarction and its intervention on blood viscosity and blood coagulation factor.Methods：A total of 110 patients with acute cerebral infarction were randomly divided into two groups,55 cases in each.The control group received the conventional treatment of acute cerebral infarction.The observation group accepted the conventional treatment of acute cerebral infarction and combined with Ligustrazine Hydrochloride Injection and Buyang Huanwu Decoction.We compared the curative effect,NHISS score,blood viscosity index and blood coagulation factors in patients of two groups.Results：Total effective rate of observation group was 92.7% which was higher than the control group＇s78.2% with significant difference（P〈0.05）.After treatment,the observation group＇s NHISS score（9.10 ± 2.23）points were lower than the control group＇s NHISS score（13.09 ± 3.57） with significant difference（P〈0.01）.After treatment,whole blood low shear viscosity（8.12 ± 3.26） m Pa·s,the whole blood high shear viscosity（4.12 ± 1.18）m Pa·s,plasma viscosity（1.22 ± 0.35） m Pa· s of the observation group were lower than the control group＇s whole blood low shear viscosity（11.33 ± 3.71） m Pa·s,whole blood high shear viscosity（6.09 ± 1.22） m Pa·s,plasmaviscosity（2.08 ± 0.54） mP a·s and there was a statistically significant difference（P〈0.01）.After treatment,the prothrombin time（13.63 ± 4.28） s,activated partial thromboplastin time（30.61 ± 8.02） s,thrombin time（23.26 ±6.09） s of the observation group were higher than the control group＇s prothrombin time（10.55 ± 3.46） s,activated partial thromboplastin time（23.29 ± 7.17） s,thrombin time（18.05 ± 4.68） s and there were statistically significant differences（P〈0.01）.After treatment,the observation group＇s fibrinogen（2.69 ± 0.33） g/L was lower than the control group＇s fibrinogen（4.14 ± 0.43） g/L and there was significant difference（P〈0.01）.Conclusion：Ligustrazine Hydrochloride Injection combined Buyang Huanwu Decoction in the treatment of patients with acute cerebral infarction has good curative effect and can improve blood viscosity and coagulation factor.