抗焦虑治疗控制进展性缺血性脑卒中发生的临床研究

Clinical study of anti-anxiety treatment to prevent the progression of ischemic stroke

目的探讨抗焦虑治疗能否有效控制进展性缺血性脑卒中的发生,为改善缺血性脑卒中的预后提供理论依据。方法采用焦虑自评量表(SAS)对治疗组和对照组共120例脑卒中患者的焦虑状态进行评价,以评估各组焦虑状态的均衡性。除常规治疗脑卒中外,治疗组加用抗焦虑药物阿普唑仑,在治疗前及治疗后三天分别由专业医师通过随机双盲的方式对患者的肌力情况进行评价,并比较两组患者出现进展性卒中发生率。结果治疗组中出现进展性卒中的发生率6.7%,对照组中出现进展性卒中的发生率21.7%,治疗组中出现进展性卒中的比例明显低于对照组,差异有统计学意义(P<0.05)。结论抗焦虑治疗早期缺血性脑卒中患者能够有效地减少进展性缺血性脑卒中的发生。

Objective To investigate the effects of intervention with anti-anxiety treatment on the clinical symptoms of patients with progressive stroke. Methods One hundred and twenty patients with stroke were selected and randomly divided into control group and treatment group. For both groups, there was no significant difference in the anxiety status evaluated by self-rating anxiety scale （SAS）. The patients of control group were treated with the conventional therapy. The patients in treatment group, in addition to the conventional therapy used in the control group, were also treated with anti-anxiety medication. For both groups, one treatment course lasted three days. The muscle strength and the incidence of progressive stroke of the two groups before and after three days of treatment were determined. Results Following treatment, the incidence of progressive stroke in the treatment group was significantly lower than those in the control group （P 〈0. 05）. It was 6.7% in treatment group and 21.7% in control group. Conclusion Anti-anxiety treatment is safe and effective to prevent the progression of ischemic stroke.