SOD、NO、TNF-α和hs-CRP对高血压合并糖尿病患者动脉粥样硬化的影响

Effects of SOD,NO,TNF- αand hs-CRP on atherosclerosis in patients with hypertension complicating diabetes mellitus

目的观察超氧化物歧化酶(SOD)、一氧化氮(NO)、肿瘤坏死因子(TNF-α)和超敏C-反应蛋白(hs-CRP)对高血压合并糖尿病患者动脉粥样硬化的影响。方法选择2010年1月至2016年1月在该院接受住院治疗的134例患者,分为高血压组患者45例、2型糖尿病组患者44例、高血压合并2型糖尿病组患者45例,检测各组患者颈总动脉内膜中层厚度(IMT)、血清SOD、NO、TNF-α和hs-CRP水平,另选该院同期健康体检者45例作为健康对照组进行对比分析。结果高血压合并2型糖尿病组的SOD、NO均明显低于健康对照组、高血压组和2型糖尿病组,差异有统计学意义(P<0.05),而TNF-α、hs-CRP、IMT水平均明显高于健康对照组、高血压组和2型糖尿病组,差异有统计学意义(P<0.05)。高血压组和2型糖尿病组SOD、NO、TNF-α、hsCRP、IMT水平比较,差异无统计学意义(P>0.05)。IMT与TNF-α、hs-CRP呈正相关(r=0.636、0.664,P<0.05),与SOD、NO呈负相关(r=-0.586、0.648,P<0.05)。结论评价氧化应激和炎症状态下SOD、NO、TNF-α和hs-CRP水平变化,能进一步探讨其发生的机制,也对高血压和糖尿病这类血管损伤性慢性疾病的预防、治疗具有一定的意义。

Objective To observe the effects of SOD,NO,TNF-αand hs-CRP on atherosclerosis in the patients with hypertension complicating diabetes mellitus（DM）.Methods One hundred and thirty-four inpatients in our hospital from January 2010 to January 2016 were selected,including 45 cases of hypertension,44 cases of type 2diabetes Mellitus（T2DM）and 45 cases of hypertension complicating T2 DM.IMT and serum SOD,NO,TNF-αand hs-CRP levels were detected.Contemporaneous 45 individuals undergoing healthy physical examination were selected as the healthy control group for conducting the contrastve analysis.Results The SOD and NO levels in the hypertension complicating T2 DM group were significantly lower thin the healthy control group,hypertension group and T2 DM group,the difference had statistical significance（P〈0.05）.The levels of SOD,NO,TNF-α,hs-CRP and IMT had no statistical significance between the hypertension group and T2 DM group（P〈0.05）.IMT was positively correlated with TNF-αand hs-CRP（r=0.636,0.664,P〈0.05）and negatively correlated with NO and SOD（r=-0.586,0.648,P〈0.05）.Conclusion Evaluating the change of SOD,NO and TNF-αand hs-CRP levels can further investigate its occurrence mechanism and also has certain significance to the prevention and treatment of vascular injury chronic diseases such as hypertension and TM.