幽门螺杆菌感染程度与胃蛋白酶原和胃癌相关肿瘤标志物的关系

Association between degree of Helicobacter pylori infection with serum pepsinogen and tumor markers related with gastric cancer

目的研究幽门螺杆菌（Hp）感染程度与胃蛋白酶原（PG）和胃癌相关肿瘤标志物的关系。方法选择2015年1-6月在该院体检的342例健康体检者,用13 C尿素呼气试验检测有无感染以及感染程度,酶标法测定PG,发光免疫法测定肿瘤标志物,并用SPSS统计软件进行统计学分析。结果 342例研究对象的Hp阳性率为49.42%,性别间差异无统计学意义（P〉0.05）。Hp（＋＋）组和Hp（＋＋＋）组中血清胃蛋白酶原Ⅰ（PGⅠ）、胃蛋白酶原Ⅱ（PGⅡ）水平显著高于阴性组,PGⅠ/PGⅡ水平则显著低于阴性组（P〈0.05）。Hp阳性（＋＋＋）组的肿瘤标志物糖类抗原724（CA724）、癌胚抗原（CEA）和阴性组比较差异有统计学意义（分别P=0.040,P=0.010）。Pearson相关分析显示：Hp感染与PGⅠ、PGⅡ、PGⅠ/PGⅡ、CA724和CEA相关;PGⅡ和糖类抗原50（CA50）呈正相关（r=0.116,P=0.032）,PGⅠ/PGⅡ和CA50呈负相关（r=-0.193,P=0.000）。结论 Hp、PG和肿瘤标志物等联合检测可以作为健康体检人群中筛查良、恶性胃病的方法之一,对于预防和干预相关疾病的发生、发展具有较为重要的价值。

Objective To study the relationship of Helicobacter pylori（Hp）infection degree with serum pepsinogen（PG）and the tumor markers related with gastric cancer.Methods Totally 342 cases of health physical check-up in our hospital from January to June 2015 were selected.13 C-UBT was performed to evaluate the Hp infection and infection severitys.The level of serum PG was detected by ELSIA and the levels of tumor markers were detected by luminescence immunoassay.Then the results were statistically analyzed with the SPSS statistical software.Results The positive rate of Hp in 342 research subjects was 49.42%,and there was no difference between the male and the female groups（P〈0.05）.The level of serum pepsinogen Ⅰ（PGⅠ）and pepsinogen Ⅱ（PGⅡ）in the Hp（＋＋）and Hp（＋＋＋）groups was significantly higher than that in the Hp negative group,while the PGⅠ/PGⅡlevel was significantly lower than that in the negative group（P〈0.05）.The level of carbohydrate antigen 724（CA724）and carcino-embryonic antigen（CEA）had the statistical difference between the Hp（＋ ＋ ＋）group and the Hp negative group（P=0.040,P=0.010）.The Pearson correlation analysis displayed that Hp infection was related with PGⅠ,PGⅡ,PGⅠ/PGⅡ,CA724 and CEA.There was a positive correlation between PGⅡ and CA50）（r=0.116,P=0.032）;there was a negative correlation between PGⅠ/PGⅡ and CA50（r=-0.193,P=0.000）.Conclusion The combined detection of Hp,PG and tumor markers could be used as one of methods for screening benign and malignant gastric diseases in the healthy physical check-up population,which has an important value for the prevention and intervention of related disease occurrence and development.