替格瑞洛联合阿司匹林治疗不稳定性心绞痛的疗效及安全性

The efficacy and safety of ticagrelor combined with aspirin in the treatment of unstable angina patients

目的探讨替格瑞洛联合阿司匹林治疗不稳定性心绞痛（UA）的临床疗效和安全性。方法109例UA患者随机分成治疗组（55例）和对照组（54例），两组患者均接受抗心绞痛常规药物治疗。治疗组在常规治疗的同时，首次H服给予负荷剂量的替格瑞洛180mg，继之90mg，每天2次。治疗期间记录心绞痛的发作情况，观察12导联心电图变化，记录药物治疗后的不良反应。2组治疗4周后比较疗效。结果与对照组相比，治疗组的心绞痛发作次数和平均发作持续时间在治疗前无差异，治疗后显著缩短，差异有统计学意义（P〈0．05）。对照组和治疗组临床疗效总有效率分别为70．4％和89．1％，差异有统计学意义（P〈0．05）。对照组和治疗组的心电图改善有效率为66．7％和87．3％，差异有统计学意义（P〈0．05）。两组均未见严重出血不良反应。结论替格瑞洛与阿司匹林联合应用治疗不稳定性心绞痛效果优于单独应用阿司匹林。

Objective To investigate the efficacy and safety of ticagrelor combined with aspirin in the treatment of unstable angina （UA） patients. Methods A total of 109 UA patients were randomly divided into a treatment group （n = 55） and a control group （ n = 54）. All patients were routinely administrated with anti - angina agents. Furthermore, the treatment group was given ticagrelor at a loading dose of 180 mg followed by 90 mg twice daily. During treatment, the incidence of angina was recorded, while the changes in 12 - lead electrocardiogram were observed. Both groups were compared after four weeks of treatment. Results Compared with the control group, the treatment group showed no statistical difference in the incidence of angina and average duration before treatment, but a remarkably reduced incidence of angina and average duration after treatment （P 〈 0, 05 ）. The total effective rate was 70.4% for the control group and 89.1% for the treatment group （P 〈 0.05）. The effective rate in electrocardiogram was 66.7% for the control group and 87.3% for the treatment group （P 〈 O. 05）. No serious adverse reactions were reported for both groups. Conclusions The combination of ticagrelor and aspirin is superior to aspirin alone in the treatment of unstable angina pectoris.