干细胞样记忆型T细胞在HIV-1感染中作用的研究

Advances in the Role of Stem Memory T Cells in HIV-1 Infection

干细胞样记忆型T细胞(Stem memory T cells,Tscm)是最早期分化的、存活时间最长的一类记忆型T细胞。这类细胞具有自我更新及多能分化等干细胞特性,其在抗肿瘤中具有重要的作用,在HIV-1感染中的作用也开始成为研究热点。本文对Tscm细胞的特点、CD4+Tscm细胞在HIV-1病毒储藏库中的重要性及CD8+Tscm细胞抗病毒作用的最新研究进行介绍。了解并充分利用Tscm细胞的特性及其在HIV-1感染中的作用,将有助于开发以Tscm为靶点的HIV-1疫苗及免疫治疗新方法,为HIV-1的防控及功能性治愈提供新的策略。

Stem memory T cells represent the earliest and long-lasting memory T cells.They display stem cell-like properties of self-renewal and multipotency.Tscm cells have shown their antitumor effect;the role of Tscm cells has sparked interest in anti-HIV fields recently.In this review,we will introduce the characteristics of Tscm cells,the importance of CD4＋Tscm cells in HIV-1latent reservoir,and the antiviral activity of CD8＋Tscm cells.Understanding the properties of Tscm cells and their potential role in antiHIV-1,will help us to explore the possibility of Tscm to be used as,or targeted by,vaccines or immunotherapies for HIV-1treatment,thereby providing new strategies for prevention,control and functional cure of HIV-1.