盐酸纳美芬对急性颅脑损伤患者脑保护作用分析

Analysis of cerebral protective effect of nalmefene hydrochloride on patients with acute craniocerebral injury

目的探讨盐酸纳美芬对急性颅脑损伤患者的脑保护作用。方法将我院2013年9月至2015年9月在我院接受治疗的80例急性中重型颅脑损伤患者纳入本研究。按照入院顺序抽签后,随机分为试验组和对照组,对照组采取降颅压、抗感染、营养支持等常规治疗。在此基础上,试验组采取盐酸纳美芬治疗,观察两组的治疗效果。结果试验组治疗效果明显优于对照组,死亡率明显低于对照组,差异有统计学意义(P<0.05);试验组治疗后,大脑中动脉收缩期峰值及舒张末期末值均明显低于对照组,差异有统计学意义(P<0.05);试验组治疗后1周、2周β-EP、DynA1-13、NSE水平均明显降低,且均明显低于对照组,差异有统计学意义(P<0.05);两组呼吸异常、心率异常发生率比较,差异无统计学意义(P>0.05)。结论盐酸纳美芬对急性颅脑损伤患者有脑保护作用,可改善患者大脑中动脉血流指标和β-EP、DynA1-13、NSE水平。

Objective To explore the protective effect of nalmefene hydrochloride on patients with acute craniocerebral injury.Methods Eighty patients with acute craniocerebral injury were randomly divided into experiment group and control group;control group was treated by intracraninal pressure,anti-infection and nutrition support;on the basis of treatment for control group,experiment group was treated by nalmefene hydrochloride.The treatment effect of the two groups was observed.Results The clinical efficacy of experiment group was better than control group,and the mortality of experiment group was lower than that of control group（P〈0.05）.The middle cerebral artery peak systolic velocity and end-diastolic pressure of experiment group after treatment were lower than those of control group（P〈0.05）.The p-EP,DynAl-13 and NSE of experiment group at 1 and 2 weeks after treatment were lower than those of control group（P〈0.05）.There was no significant difference in the rates of abnormal respiratory and heart rate between the two groups（P 〉0.05）.Conclusion Nalmefene hydrochloride has protective effect on the brain of patients with acute craniocerebral injury,and can improve the levels of middle cerebral artery blood index,p-EP,DynAl-13 and NSE.