阿尔茨海默病和轻度认知功能障碍相关生物学标志物

Progress in biological markers for Alzheimer＇s disease and mild cognitive impairment

阿尔茨海默病的发病率在不断增高，轻度认知功能障碍被认为是介于正常老化和痴呆之间的一种认知状态，目前二者的诊断仍然比较困难，主要依赖于患者的临床症状及相应的评估量表，而生物学标志物在临床上应用较少。本文就目前提出的常见的阿尔茨海默病和轻度认知功能障碍相关的生物学标志物进行概述，以期对临床的应用提供参考。

With the aggravation of aging of the population,the incidence of Alzheimer＇s disease （AD）has been steadily increasing, mild cognitive impairment（MCI）is considered as a cognitive state between aging and dementia. However, the diagnosis of AD and MCI is difficult and mainly depends on the clinical symptoms and the corresponding assessment scales, lacking of the application of biological markers. In this paper, we presented a general review of the biological markers related to AD and MCI,so as to provide reference for their clinical use.