常见抗菌药物在肥胖人群中剂量换算及临床应用的研究进展

The research on the clinical efficacy of antibiotic therapy and dose adjustments in the obese population

探讨肥胖特殊人群抗菌药物的合理使用。本文对临床常用的抗菌药物在肥胖人群中临床应用进行汇总,对肥胖的分类、常见的体重指标公式换算、抗菌药物的药动学等均有所涉及。肥胖患者的药动学参数发生改变,要达到目标治疗浓度需进行剂量的调整。肥胖患者在应用抗菌药物过程中,应结合抗菌药物的药动学特性,合理使用抗菌药物。

To explore the rational use of antibiotics in the obese population. In this review, published data regarding several antimicrobial drugs are summarized, including different obesity classifications, body weight descriptions, dosing recommendations of commonly used antibiotics in obesity. The pharmacokinetic parameters of obese patients were different from those of the non-obese patients, and thus the doses should be adjusted to achieve the targeted treatment concentrations. In the application of antibiotics, it is necessary to utilize pharmacokinetic pharmacology parameters of antibiotics to promote the rational use in obese patients.