抑郁情绪对冠心病患者干扰抑制功能的影响

Effects of depression on interference suppression function in patients with coronary heart disease

目的探讨抑郁水平对冠心病（coronaryheartdisease，CHD）患者干扰抑制功能的影响。方法根据抑郁自评量表（SDS）得分和中国精神障碍分类与诊断标准（CCMD-3）选取2013年5月至2015年3月在潍坊医学院附属医院心内科住院的CHD患者60例（其中CHD伴抑郁症患者15例、CHD伴抑郁情绪者21例、单纯CHD患者24例），对其进行情绪词Stroop测验，记录反应时和正确率。结果①同单纯CHD组相比，CHD伴抑郁症组的反应时更长（F（2.57）=71．97．P〈0．01），CHD伴抑郁症组和CHD伴抑郁情绪组的正确率更低（F（2.57）=8．78，P=0．04）。②CHD伴抑郁症组和CHD伴抑郁情绪组对负性词的反应时[分别为（872．77±348．47）ms，（796．53±200．92）ms]均长于正性词[分别为（809．22±343．45）ms，740．85±177．82）ms]，差异有统计学意义（P〈0．01）。⑧CHD伴抑郁症组和CHD伴抑郁情绪组负性词的干扰效应[分别为（35．48±181．97）ms，（7．16±200．06）ms]均大于单纯CHD组[（-19．86±177．82）ms]，差异有统计学意义（P〈0．01）。结论CHD伴抑郁症患者和CHD伴抑郁情绪患者对负性情绪信息均存在干扰抑制功能障碍，提示着CHD伴抑郁个体的认知控制功能受损。

Objective To investigate the level of depression on interference suppression function in patients with coronary heart disease （CHD）. Methods 15 CHD patients with major depression, 21 CHD patients with mild depression and 24 CHD patients without depressive symptoms in the Affiliated Hospital of Weifang Medical University from May 2013 to March 2015 were selected to complete the Emotional Stroop task and record their accuracy and reaction time according to the Self-Rating Depression Scale （SDS） and Classification and Diagnostic Criteria of Mental Disorders in China-Third Edition （CCMD-3）. Results （1） The reaction time was longer （F（2,57）= 71.97, P〈0.01）and the accuracy was lower （F（2,57）= 8.78, P=0.04） in CHD with major depression group and CHD with mild depression group compared with CHD group.（2） The reaction time of negative words （（872.77±348.47） ms, （796.53±200.92）ms） was longer than positive words （（809.22±343.45） ms, （740.85±177.82）ms） in CHD with major depression group and CHD with mild de- pression group.（3） The interference effect of negative words was bigger in CHD with major depression group and CHD with mild depression group （（35.48±181.97）ms, （7.16±200.06）ms） compared with CHD group （（-19.86±177.82）ms）. Conclusion Both CHD patients with major depression and CHD patients with mild depression have deficits in interference inhibition for negative information ,which suggests that CHD with depressive individuals have impaired cognitive control function.