云南大理白族血清尿酸与代谢综合征及危险因素相关性研究

Correlation study between serum uric acid and metabolic syndrome and risk factors in Dali Bai population in Yunnan

目的探讨云南大理白族血尿酸的分布特点与代谢综合征(MS)及其危险因素的相关性。方法对5 444例包括城市、农村、城乡结合部居住5年以上的大理白族人群进行问卷调查、体格检查和生化指标进行分析。结果1随着血尿酸水平升高,研究对象收缩压、舒张压、甘油三酯、低密度脂蛋白胆固醇、体质量指数、腰臀比逐渐上升,高密度脂蛋白胆固醇逐渐下降(P<0.01);随着血尿酸的升高,空腹血糖、糖化血红蛋白男性差异无统计学意义(P>0.05),女性呈逐渐升高趋势(P<0.01);2高尿酸血症(HUA)及MS患病率男性高于女性;随着年龄增加,患病率逐渐升高(P<0.01);农民、城镇居民、城乡结合部居民患病率逐渐升高(P<0.01)。吸烟史、饮酒史、代谢病家族史男性高于女性(P<0.01);农民、城镇居民、城乡结合部居民所占比例逐渐升高(P<0.01);随着年龄的增加,吸烟史所占比例逐渐下降,饮酒史呈中年增高趋势而代谢疾病家族史呈中年下降趋势(P<0.01)。3随着血尿酸升高,男女性MS患病率逐渐升高(P<0.01)。4MS患病与UA水平有关。在同一年龄组,随着UA水平的增加,MS患病风险呈增加趋势,特别是中、老年女性。结论云南大理白族HUA患病率高,血尿酸水平与MS有关,血尿酸升高是MS的独立危险因素。

Objective In order to investigate the correlation between serum uric acid and metabolic syndrome（MS）and their risk factors.Methods A total of 5 444 cases from Bai population,including urban,rural,urban fringe living for more than five years,were analyzed by questionnaire,physical examination and biochemical parameters.Results 1 With the level of uric acid elevated,the systolic blood pressure,diastolic blood pressure,triglycerides,low-density lipoproteins cholesterol,body mass index,waist-hip ratio increased gradually in both men and women,however,high-density lipoprotein protein cholesterol decreased（P 0.01）;though fasting blood glucose and glycated hemoglobin in men showed no significant change with serum uric acid elevated（P 0.05）,but,the indexes increased gradually in women（P 0.01）;2The prevalence of hyperuricemia（HUA）and metabolic syndrome in men were higher than in women;with increasing age,the prevalence increased gradually（P 0.01）;the prevalence in urban,rural,urban fringe population increased gradually（P 0.01）.The smoking history,drinking history and family history of metabolic disease：the proportion in men was significantly higher than in women（P 0.01）;the proportion in urban,rural,urban fringe population increased gradually（P 0.01）;with increasing age,the proportion of smoking history,alcohol consumption history decreased gradually（P 0.01）;3With the level of uric acid elevated,the prevalence of MS and its components increased gradually in both men and women（P 0.01）.4Logistic regression analysis showed that the level of serum uric acid was positively correlated with the prevalence of MS in both men and women,especially in women from Dali Bai population.Conclusion The prevalence of HUA was high in Yunnan Dali Bai population,the level of serum uric acid was positively correlated with MS,and increasing uric acid was an independent risk factor of MS.