基于金纳米棒组装的半胱氨基酸分子同手性识别

Thehomochiral recognition of cysteine based on the assembly of gold nanorods

本文通过半胱氨酸分子诱导金纳米棒自组装形成一维线性链状结构,利用停留装置观察了不同手性的半胱氨酸分子(L/D-半胱氨酸)诱导金纳米棒自组装的动力学过程.通过调控CTAB浓度,首次发现在组装速率很快的情况下,L-半胱氨酸分子诱导金纳米棒自组装的组装速率慢于D-半胱氨酸分子.而在组装速率较慢的情况下,这种情况不存在.通过分析揭示了为什么在慢速动力学和快速动力学会出现这种差异.并对在快速动力学下不同手性分子在诱导纳米颗粒组装上不同动力学行为作出讨论.这一工作可能为进一步解释生命的单一手性现象提供线索.

In this work,Cysteine were exploited to induce the linear self-assembly of gold nanorods. Kinetics of the assembly process triggered by Cysteine molecules with distinct chirality（L-/D-Cysteine） were investigated in STOPPED-FLOW machine. It was first found that the assembly rate was higher for D-Cysteine in the fast kinetic,but there is no difference in the slow kinetic. We reveal why there is difference between slow kinetic and fast kinetic after analysis,and discuss the different behavior of D/L-Cysteine in inducing the assembly of nanorods in fast kinetic. This work may provide clues for further explaining the homochirality of life.