高迁移率族蛋白1与急性肾损伤的研究进展

Research progress of HMGB1 and acute kidney injury

高迁移率族蛋白1(high-mobility group protein 1,HMGB1)是真核细胞核内蛋白,其作为晚期炎症介质的作用得到广泛关注。研究表明,HMGB1参与了多种疾病的进展,如急性肾损伤、恶性肿瘤、脓毒症、抗中性粒细胞胞浆抗体相关性血管炎等。在这篇综述中,笔者专注于HMGB1的生物学及其与各种病因引起的急性肾损伤的关联。

HMGBl（high-mobility group 1 protein, HMGB1） is the nuclear protein in eukaryotic cells, which has been widely researched as a late inflammatory mediators. Studies show that HMGB1 is involved in the progression of many diseases, such as malignant tumor, acute kidney injury, sepsis, anti neutrophil cytoplasmic antibody associated vasculitis. In this review, we focus on the biological function of HMGB1 and the relevance to HMGB1 and acute kidney injury caused by various causes.