植物免疫中的EDS1

EDS1 in Plant Innate Immunity

EDS1(enhanced disease susceptibility 1)是一种重要的防卫基因,其编码的信号蛋白质位于植物免疫信号网络的关键节点。EDS1的互作蛋白质包括PAD4(phytoalexin defi ciency 4)和SAG101(senescence-associated gene 101)。EDS1在以TIR-NB-LRR(toll-interleukin-1 receptornucleotide binding-leucine-rich repeat)类R蛋白(resistance proteins)为主介导的ETI(effectors-triggered immunity)及不涉及R蛋白的PTI(PAMP-triggered immunity)中均发挥重要作用,主要调控细胞内氧爆发和水杨酸(salicylic,SA)的积累并抑制JA/ET(jasmonic acid/ethylene)通路。该文就EDS1蛋白质的结构特点及其在植物防卫病菌入侵的信号通路中的功能作一综述。

EDSI （enhanced disease susceptibility 1） is an important defense gene which codes a signal protein. The protein locates in the key node of plant innate immune signal network. PAD4 （phytoalexin deficiency 4） and SAG 101 （senescence-associated gene 101） are signaling partners of EDS 1. EDS 1 plays important roles in ETI （effectors-triggered immunity） which is mainly mediated by TIR-NB-LRR （toll-interleukin-1 receptor-nucleotide binding-leucine-rich repeat） resistance proteins and PTI （PAMP-triggered immunity） which is not mediated by any R proteins （resistance proteins）. EDS1 primarily regulates intracellular ROS （reactive oxygen species） burst and SA （salicylic） accumulation as well as suppresses JA/ET （jasmonic acid/ethylene） signal pathway. This paper reviews the structure of EDS 1 protein as well as its important roles in defense signal pathways.