Beclin1-Vps34在自噬发生发展中的作用

The Role of Beclin1-Vps34 in the Development of Autophagy

自噬是一种关于长寿蛋白质和缺陷细胞器降解且溶酶体依赖的细胞代谢过程,对于维持细胞稳态和避免细胞衰老至关重要。最新研究表明,Beclin1-Vps34复合体既参与自噬调控又在肿瘤的形成及发展中起关键作用。该文综述了不同Beclin1-Vps34作用分子及其如何促进或抑制自噬,简介了以Beclin1-Vps34为靶标的癌症治疗最新研究进展,并提出了其未来发展的新方向。

Autophagy is a lysosome-dependent cellular catabolic process involved in the degradation of long-lived proteins and defective organelles. It is essential to maintain cellular homeostasis and to avoid cellular senescence. Current studies demonstrate that Beclinl-Vps34 complexes not only involved in autophagy regulation but also played a key role in tumor formation and development. This review focuses on the different Beclinl-Vps34 interacting partners, and how they associate in various ways to promote or inhibit autophagy. Here we sumarises the latest progress of Beclinl-Vps34 as the target of cancer treatment, and then raised new directions for future development.