应用红外热成像技术评价定坤丹靶向药效

Infrared thermal imaging assesses the targeting property of Dingkun Pellet

目的应用红外热成像技术进行定坤丹的动态靶向药效的评价。方法 2011年和2012年夏季,从募集的痛经人群中筛选出8例阳虚体质、寒凝血瘀型的原发性痛经受试者进行自身对照实验。在其服用温水及定坤丹时运用HIR-2000型红外热像诊断系统进行进行104例次全身扫描,并测定全身15个区位的绝对热值和背景热值,计算相对热值及趋势图。所有数据均在SPSS 13.0下进行分析。结果温水在头后位上部、头后位中部、督脉、神阙、下腹、子宫、附件等7个区位有提高基础热值的作用,作用趋势为单峰型;定坤丹在除心前区、下腹、足正位、足后位等区位外的其它11个区位均能提高基础热值,除头后位上部、头后位中部、督脉、附件等4个有效区位外,定坤丹对有效区位的药物作用均呈双峰型;定坤丹治疗一个月经周期后,受试者痛经症状评分、阳虚体质评分、中医证候评分较治疗前下降,有效区位中,头后位上部区位热值明显提高。结论定坤丹的靶向性集中在与双眼底供血,脑供血,末梢循环和生殖相关的区位。定坤丹通过提高子宫区位的基础热值来直接治疗寒凝血瘀型痛经。

AIM To dynamically assess the targeting properties of Dingkun Pellet（ DP） using infrared thermal imaging technology. METHODS In this self-control experiment,eight primary dysmenorrhea subjects with Yang deficiency and cold stagnation and blood stasis were collected during the summer of year 2011 and 2012,and then underwent the whole body scanning,which reached up to 104 case-times with HIR-2000 type infrared thermalimager. The absolute and the background thermal values of fifteen locations for each subject,the relative thermal values were calculated and the trend was analyzed. All data were analyzed by SPSS 13. 0. RESULTS Warm water had the effect of increasing the relative thermal value of seven locations,including superior posterior of the head,middle posterior of the head,Du channel,Shenque（ CV8）,lower abdomen,uterus,adnexa. The trend of drug effects were unimodal. Dingkun Pellet had the effects of increasing the relative thermal value of eleven locations,except precordia,lower abdomen,feet front area,feet back area. The trend of drug effects were bimodal,except four effective locations. They were superior posterior of the head,middle posterior of the head,Du channel and adnexa. After taking Dingkun Pellet for one menstrual cycle,the scores of symptoms,TCM syndrome and Yang deficiency constitution of all subjects were decreased. The thermal values were apparently improved in superior posterior of the head among effective locations. CONCLUSION The targeting locations of Dingkun Pellet focuses on fundus blood flow,brain blood supply,peripheral circulation and reproduction,and its effect is related to the increase in the basic thermal value of uterus treating cold stagnation and blood stasis dysmenorrhea.