Fascin-2基因功能的研究进展

Research progress of Fascin-2 gene function

Fascin-2基因属于Fascins家族,其蛋白质编码产物是一组结构独特、进化保守的肌动蛋白交联蛋白,位于细胞膜皱襞、微棘突起及应力纤维,控制肌动蛋白细丝平行、有序、紧密排列与聚集。近年来研究发现,Fascin-2基因与连接以肌动蛋白为基本成分的纤毛质膜有密切联系,从而在感光器圆盘以及毛细胞静纤毛的形成中起重要作用,Fascin-2突变可引起原发性视网膜色素变性及渐进性的听力减退。就Fascin-2基因的研究进展进行阐述。

Fascin-2 gene, an actin cross-linking protein found in membrane ruffles, microspikes, and stress fibers, controis the parallel, sequential, and tight alignment and aggregation of actin filaments. Recent researches have found that Fascin-2 gene is associated with the cilia of plasma membrane, whose basic composition is actin; Fascin-2 gene plays an important role in the formation of photoreceptor disk and stereocilia; the mutation of Fascin-2 gene may cause progressive retinitis pigmentosa and hearing loss. This paper will elucidate the latest research progress on Fascin-2 gene.