黄酮抗癌作用研究进展

Review on Anticancer Effects of Plant-based Flavonoids

黄酮作为一种多酚化合物,广泛存在于果蔬、花果、茶叶和蜂蜜中。流行病学数据表明,食用黄酮类化合物可以降低癌症发病的风险。黄酮类化合物具有显著的药理作用,如抗氧化、抑制蛋白激酶、抑制拓扑异构酶、抑制血管再生、激活癌细胞DNA反应通路、诱导癌细胞自吞噬、阻断癌细胞分裂周期、诱导癌细胞凋亡等方面。其机理可能与相关蛋白激酶、拓扑异构酶、血管内皮生长因子、5'-腺苷酸活化蛋白激酶、DNA损伤反应途径和细胞凋亡途径等有关。本综述为进一步了解黄酮可能的抗癌功能提供帮助。

Flavonoids,which are polyphenolic phytochemicals generally found in vegetables,fruits,flowers,nuts,seeds,tea,and honey. There is epidemiological data to suggest that consumption of flavonoids can be accompanied by decreased cancer incidence. Flavonoids has therapeutic applications owing to its wide range of pharmacological effects including antioxidant,inhibition of protein kinase,inhibition of topoisomerase,inhibition of angiogenesis,activating the DNA damage response,inducing the autophagy,blocking the cell cycle,and inducing apoptosis. The antitumor effect of flavonoids and its underlying mechanism are related to interactions with protein kinase,topoisomerase,vascular endothelial growth factor,5＇-adenosine monophosphate-activated protein kinase,DNA damage response pathway,apoptotic pathways. This review contributed to clarifying the mechanisms of the actions of flavonoids in anticancer effects.