红细胞免疫指标与T淋巴细胞亚群及免疫球蛋白水平在慢性HBV感染中的价值研究

Detection values of erythrocyte immunity index,T lymphocyte subsets and immunoglobulin levels in patients with chronic HBV infection

目的探讨红细胞免疫指标、T淋巴细胞亚群及免疫球蛋白水平在慢性乙型肝炎病毒(HBV)感染检测中的价值,为临床治疗提供参考依据。方法 2015年5月-2016年5月分别采用郭氏法、流式细胞术和免疫散射法检测224例HBV感染患者全血标本,其中慢性乙型肝炎组患者126例和肝硬化组患者98例,选取同期健康体检者102例为对照组,比较3组红细胞免疫指标。结果各组红细胞免疫指标、T淋巴细胞亚群及免疫球蛋白水平比较,差异均有统计学意义(P<0.05);logistic回归模型分析,RBC-C3bR、RBC-ICR、IgG的危险度分别为5.34、5.16、4.56,可作为肝硬化发生的独立危险因素。结论在HBV感染、慢性乙型肝炎、肝硬化的发展过程中存在红细胞免疫、T淋巴细胞亚群及免疫球蛋白的改变,其中RBC-C3bR、RFER、IgG指标的变化与肝硬化发生密切相关。

OBJECTIVE To discuss the values of erythrocyte immunity index,T lymphocyte subsets and immunoglobulin levels in patients with chronic hepatitis B virus（HBV）infection detection,so as to provide references for clinical treatment.METHODS From May 2015 to May 2016,whole blood specimens of 224 cases of HBV infection patients were detected by Kuok,flow cytometry and immunohistochemistry scattering method,of which chronic hepatitis B infection group with 126 cases and cirrhosis group with 98 cases,and 102 cases of healthy volunteers during the same period were set as control group.The erythrocyte immunity indexes were compared.RESULTS There were significant differences in erythrocyte immunity indexes,T lymphocyte subsets and immunoglobulin levels among different groups（P〈0.05）.Logistic regression analysis showed that the risks of RBC-C3 bR,RBCICR and IgG were 5.34,5.16 and 4.56,respectively,which could be used as independent risk factors for cirrhosis.CONCLUSIONErythrocyte immunity indexes,T lymphocyte subsets and immunoglobulin levels are changing in the development of HBV infection,chronic hepatitis and cirrhosis,of which RBC-C3 bR,RBC-ICR and IgG are closely related to for cirrhosis.