颅脑动脉瘤夹闭术后患者感染病原菌分布及对球蛋白水平影响研究

Pathogen distribution and its effect on serum globulin level in cerebral aneurysms patients after clipping

目的对颅脑动脉瘤夹闭术后脑血管痉挛患者感染病原菌分布及对患者血清球蛋白表达的影响进行研究,为临床诊治提供参考依据。方法对医院2010年1月-2014年11月期间诊治210例颅脑动脉瘤夹闭术后脑血管痉挛感染患者为感染组,以医院同期健康体检者210名为对照组,颅脑动脉瘤夹闭术后脑血管痉挛未感染患者600例设为未感染组,分析病原菌分布及临床指标。结果感染组患者中共分离210株病原菌,以革兰阳性菌为主,共107株占51.0%;感染患者血清球蛋白、白蛋白及血清总蛋白水平明显低于对照组和未感染组患者,而血清JAK1、JAK3和STAT1及STAT2蛋白水平明显高于对照组和未感染组患者,差异均有统计学意义(P<0.05)。结论颅脑动脉瘤夹闭术后脑血管痉挛患者容易受到病原菌感染,且感染引起患者血清白蛋白和球蛋白水平降低和JAK/STAT通路蛋白表达的升高。

OBJECTIVE To analyze the pathogen distribution and its effects on serum albumin concentration in cerebral vasospasm patients after cerebral aneurysms clipping,so as to provide references for clinical diagnosis and treatment.METHODS A total of 210 cases of infected cerebral aneurysms patients from Jan.2010 to Nov.2014 were selected as infection group,210 cases of healthy persons were selected as control group,and 600 cases of uninfected cerebral aneurysms patients at the same period in our hospital were taken as non-infection group.The distribution of pathogen and clinical indexes were analyzed.RESULTS Totally 210 strains of pathogens were isolated from the infected patients,and mainly were 107 strains of gram-positive bacteria,accounting for 51.0%.The serum globulin,albumin and total protein levels of infection group were all significantly lower than those of control group and non-infection group,while the JAK1,JAK2,STAT1 and STAT2proteins levels were all significantly higher than those of control group and non-infection group（P〈0.05）.CONCLUSION Cerebral vasospasm patients after cerebral aneurysms clipping are suffered from pathogen infection,and the infection will cause the decrease of serum albumin and globulin levels,as well as the increase of the expression of JAK-STAT signaling pathway related proteins.