神经特异性烯醇化酶表达与重症肠道病毒71型感染患儿预后的关系

Relationship between expression of neuron-specific enolase and prognosis of children with severe enterovirus 71 infection

目的明确重症肠道病毒71型感染患儿预后与神经特异性烯醇化酶表达的关系。方法选取2014年2月-2015年6月医院收治的肠道病毒71型重症感染患儿76例,比较预后良好与预后较差患儿血清神经特异性烯醇化酶水平,计算神经特异性烯醇化酶评估患儿预后的灵敏度、特异度和相对危险度。结果 76例重症肠道病毒71型感染患儿,GOS 1~3分患儿34例,GOS 4~5分患儿42例,神经特异性烯醇化酶分别为（37.27±8.62）μg/L、（18.31±4.78）μg/L;以血清神经特异性烯醇化酶30μg/ml为标准评估重症肠道病毒71型感染患儿预后,灵敏度为70.59%,特异度为76.19%,相对危险度为1.94。结论神经特异性烯醇化酶与重症肠道病毒71型患儿的预后具有明显相关性,其浓度越高,患儿预后越差,可作为评估预后的参考指标。

OBJECTIVE To define the relationship between expression of neuron-specific enolase and prognosis of children with severe enterovirus 71 infection.METHODS A total of 76 children with severe enterovirus 71 infection who were treated in the hospital from Feb 2014 to Jun 2015 were enrolled in the study.The level of serum neuronspecific enolase was compared between the children with favorable prognosis and the children with poor prognosis;the sensitivity,specificity,and relative risk of the neuron-specific enolase in assessment of the prognosis were calculated.RESULTS Of the 76 children with severe enterovirus 71 infection,34got the GOS varying from 1to 3points,and 42 got the GOS varying from 4to 5points;the levels of neuron-specific enolase were（37.27±8.62）μg/L and（18.31±4.78）μg/L,respectively.As 30μg/ml of serum neuron-specific enolase was set as the standard for assessment of the prognosis of the children with severe enterovirus 71 infection,the sensitivity was 70.59%,the specificity 76.19%,the relative risk 1.94.CONCLUSIONThe neuron-specific enolase is remarkably associated with the prognosis of the children with severe enterovirus 71infection;the higher the concentration of the neuronspecific enolase,the poorer the prognosis of the children is,and it can be served as a reference index for assessment of the prognosis.