黄嘌呤氧化酶在HFrEF患者血清中的水平及相关因素

Relevant factors and levels of serum XO in heart failure patients with reduced ejection fraction

目的探讨射血分数减低的心力衰竭(HFr EF)患者血清中黄嘌呤氧化酶(XO)水平及其与心脏脂肪酸结合蛋白(H-FABP),金属蛋白酶(MMP)-2,MMP-9的相关性。方法选取新疆维吾尔自治区人民医院心内科住院确诊为HFr EF患者40例(HFr EF组),健康体检正常者40例(对照组),分别测量两组患者的身高、体质量、血压,留取空腹静脉血,采用酶联免疫吸附实验分别检测两组血清中XO、H-FABP、MMP-2、MMP-9水平。结果与对照组比较,HFr EF组患者血清中XO水平显著高于对照组(P<0.05)。多元线性逐步回归分析显示,H-FABP,MMP-2和MMP-9是影响血清XO水平的独立相关因素。HFr EF组患者血清XO水平与H-FABP,MMP-2和MMP-9呈正相关(分别r=0.787,r=0.838和r=0.864,均P<0.01)。结论 HFr EF患者血清中XO水平均显著增高,且血浆XO水平与H-FABP,MMP-2和MMP-9相关。

AIM To investigate the levels of serum xanthine oxidase （XO） in heart failure patients with reduced ejection fraction （EF） and to study the possible correlations of serum XO levels with heart fatty acid binding protein （H-FABP） and matrix metalloproteinases-2, -9 （ MMP-2, MMP-9）. METHODS A total of 80 patients who were hospitalized or undergoing physical examination at the People＇s Hospital of Xinjiang Uygur Autonomous Region were divided into heart failure with decreased EF group （n = 40） and control group （n = 40）. Height, weight and blood pressure were measured in all patients. Fasting venous blood samples were collected and the levels of serum XO, H-FABP, MMP-2 and MMP-9 were tested by enzyme-linked immunosorbent assay （ELISA）. RESULTS Compared with control group, serum XO levels in heart failure group significantly increased （ P 〈 0. 05 ）. In heart failure group, serum XO levels were positively correlated with H-FABP, MMP-2 and MMP-9 （ r = 0. 787, 0. 838 and 0. 864, respectively; P 〈0. 01 ）. Multiple linear stepwise regression analysis showed that H-FABP and MMP-2 and MMP-9 were independent factors affecting serum XO levels （ P 〈 0.01 ）. CONCLUSION Serum XO levels in heart failure patients with reduced ejection fraction decrease significantly and serum XO levels are associated with heart fatty acid binding protein and matrix metalloproteinases-2, -9.