全吸收式血管支架的临床研究进展

Clinical advances in research of fully bioresorbable scaffolds

经皮冠状动脉介入(PCI)治疗已经成为冠心病患者冠脉血运重建的主要手段。第二代金属药物洗脱支架(DES)虽然较以往裸金属支架显著减少了支架内再狭窄和靶病变再次血运重建的发生率,但仍不能从根本上解决支架长期存留带来的问题。新型可吸收支架早期提供血管支撑,随后完全消失,从根本上克服了支架永久存留的不足,成为目前心血管介入领域研究的焦点。本文就目前主要的全吸收式血管支架的种类及相关临床研究进行概述。

Percutaneous coronary intervention （PCI） has become the major method to treat coronary artery diseases （CAD）. Second-generation drug-eluting stents （DES） have significantly reduced the occurrence of in-stent restenosis （ISR） and target lesion revascularization （TLR） compared with bare metal stents. However, DES cannot fundamentally resolve the problem caused by permanent mental stents. Fully bioresorbable scaffolds （BRS） are designed to provide temporary support to the vessel walls and subsequently dissolve. BRS have become the focus of current cardiovascular intervention due to the theoretical advantages of the new technology. This article will review the main types of BRS, relevant clinical research and limitations.