摘要
选择L-半胱氨酸为中心分子,设计合成了两亲性载体mPEG-Cys-AFC偶联体,其中4-三氟甲基-6-氨基香豆素(AFC)为模型药物.通过1 H NMR、13 C NMR和MALDI-TOF-MASS对化合物结构进行了表征.采用水溶法制备了胶束,利用芘荧光探针法确定了临界胶束浓度(CMC)为92.8mg/L,测得胶束的平均粒径为141.1nm,Zeta电位为-6.11mV.经测定表明,在PGA酶作用下载体化合物能迅速控释模型药物分子.
In this paper, L-cysteine was selected as center molecule, amphiphilic carrier conjugate mPEG-Cys- AFC, and AFC （4-trifluoromethyl-6-amino-coumarin） was designed and synthesized as a model drug. The structure of conjugate was characterized via 1H NMR, laC NMR and MALDI-TOF-MASS. Micelles were pre- pared by the solution method, and using Pyrene fluorescence probe method the critical micelle concentration （CMC） was determined as 92.8 mg/L. The particle size of the micelles and Zeta potential were 141.1 nm and --6.11 mV, respectively. The results showed it rapidly controlled and released of a model drug molecule under the influence of PGA enzyme.
出处
《延边大学学报（自然科学版）》
CAS
2016年第3期207-211,251,共6页
Journal of Yanbian University（Natural Science Edition）
关键词
药物载体
两亲性
胶束
酶促控释
drug carriers amphipathic
micelle
enzymatic controlled release
