miRNA靶向RAS-MAPK通路的表观遗传性激活与肿瘤

Epigenetic activation the miRNAs target the RAS-MAPK pathway and cancer

肿瘤作为一种难治性疾病,全世界都在为其治疗寻找新靶点。高度保守的RAS-MAPK通路在生物界大多数细胞内都广泛存在,主要通过各种级联反应刺激来控制细胞增殖分化等功能。体细胞基因突变编码RAS-MAPK通路经常发生在许多肿瘤中。mi RNAs作为近年来研究较多的一种基因表达调控方式,其是通过与相关靶基因3’-UTR区结合来降解m RNA或抑制翻译表达。明确mi RNA调控R A S-MAPK在肿瘤发生发展中的机制,可能为肿瘤的治疗提供新靶点。

As a refractory disease, people all over the world are looking for new targets for the treatment of tumor. The highly conserved RAS-MAPK pathway is involved in a wide range of cellular processes. It works with a variety of cascading reaction to control cell proliferation differentiation and other functions. Somatic genes mutations encoding the RAS-MAPK pathway often occur in many tumors. MicroRNAs are researched as a way of regulating the genic expression in recent years, and they degrade the mRNA or inhibit the translation by targeting the gene 3＇-UTR region. Understanding the mechanism of how miRNA regulates the RAS-MAPK in the development of tumor may provide new targets for the treatment of tumor.