紫杉醇联合三维适形放疗治疗局部晚期非小细胞肺癌的临床观察

Efficacy of taxol combined with three dimensional conformal radiotherapy for locally advanced nonsmall cell lung cancer

目的探讨紫杉醇（TXT）联合三维适形放疗（3D-CRT）治疗局部晚期（Ⅲ期）非小细胞肺癌的疗效。方法选取2013年1月至2016年1月间武汉大学人民医院收治的160例非小细胞肺癌ⅢA-ⅢB期患者,采用随机数字表法分为观察组和对照组,每组80例。观察组患者予以TXT联合3D-CRT治疗,对照组患者予以紫杉醇联合卡铂（TP方案）化疗,治疗3个疗程后进行疗效评价,比较两组患者的疗效和不良反应发生情况。结果观察组患者部分缓解率（PR）高于对照组患者,两组比较差异有统计学意义（P〈0.05）,疾病进展率（PD）低于对照组患者,两组比较差异有统计学意义（P〈0.01）。对照组患者胃肠道反应、骨髓抑制和肝功能损害发生率均高于观察组患者,两组比较差异均有统计学意义（均P〈0.05）。结论紫杉醇联合三维适形放疗治疗局部晚期非小细胞肺癌具有较好的临床效果,提高了药物的抗肿瘤作用,降低了不良反应的发生。

Objective To explore the efficacy of taxol（ TXT） combined with three dimensional conformal radiotherapy（ 3D-CRT） for locally advanced non-small cell lung cancer（ NSCLC）. Methods One hundred and sixty patients with stage ⅢA ~ ⅢB NSCLC treated at The People＇s Hospital of Wuhan University were randomly divided into an observation group and a control group from January 2013 to January2016,with 80 patients in each group. Patients in the observation group were given TXT combined with 3DCRT and patients in the control group were given TXT combined with carboplatin（ TP regimen） chemotherapy. Efficacy and adverse reactions were evaluated after 3 courses of treatment. Results Part remission（ PR） in the observation group was higher than that in the control group（ P〈0. 05）,while progressive disease（ PD） in the observation group was lower than that in the control group（ P〈0. 01）. Adverse reactions including gastrointestinal tract reaction,bone marrow suppression and liver dysfunction in the control group were higher than those in the observation group（ P〈0. 05）. Conclusion TXT combined with 3D-CRT is effective for locally advanced NSCLC. It not only improves anti-tumor effects but also reduces the incidence of advance effects.