摘要
【目的】探讨高危老年骨质疏松症（0P）患者多种骨代谢生化指标检测的临床意义。【方法】选取本院收治的老年OP患者（B组，n=67）、高危老年OP患者（A组，n=75）及同期入院体检无OP的老年人（对照组，n=52）为研究对象，测量比较其腰椎L2～4正位和股骨颈骨密度（BMD），测定骨代谢指标血清钙（Ca）、磷（P）、β胶原特殊序列（β-CTX）、N端骨钙素（N—MID）、总Ⅰ型胶原氨基端前肽（PINP）、25-羟基维生素D[25-（OH）D3]水平。【结果】三组Ca、P水平相比较差异无显著性（P〉0．05）；B组PINP、β-CTX高于A组和对照组，N-MID、腰椎L2～4及股骨颈BMD低于A组和对照组，且差异有显著性（P〈0．05），其余指标比较差异均无显著性（P〉0．05）；A组PINP高于对照组，且差异有显著性（P〈0．05）；B组、A组25-（OH）D3低于对照组，差异有显著性（P〈0．05），B组、A组组间比较差异无显著性（P〉0．05）。【结论】临床可通过动态监测PINP、25-（OH）D3水平变化辅助筛查高危老年OP。
[Objective]To investigate the clinical significance of bone metabolism biochemical indexes detection in high-risk elderly patients with osteoporosis （OP）. [Methods]Elderly patients with OP （group B, n = 67）, elderly patients with high-risk of OP （group A, n = 75） and elderly patients without OP （control group, n= 52） were selected as study subjects. Bone mineral density （BMD） of lumbar L2-4 and femoral neck was measured. Levels of bone metabolism indexes, including serum calcium （Ca）, phosphorus （P）, β-Crosslaps （β-CTX）, N-terminal osteocalcin （N-MID）, total collagen type I amino-terminal propeptide （PINP） and 25-hydroxy vitamin D [25- （OH） D3] were determined. [Results]There were no significant differences in serum Ca and P between the three groups （ P 〉0.05）. P I NP and β-CTX in group B were higher than those in group A and the control group while N-MID and BMD of lumbar L2-4 and femoral neck were lower in group B than those in group A and the control group（ P 〈0.05）. There were no significant differences in other indexes （P 〉0.05）. There was significant difference in PINP between group A and the control group （ P 〈0.05）. The 25-（OH） D3 in group B and group A were lower than that in control group （ P 〈0.05）, but there was no significant difference between group A and group B （ P 〉0.05）. [Conclusion]Dynamic monitoring of changes of levels of PINP and 25-（OH） D3 can be used to screen elderly patients with high risk of OP.
出处
《医学临床研究》
CAS
2016年第11期2157-2159,共3页
Journal of Clinical Research
