尿视黄醇结合蛋白及尿α1酸性糖蛋白在糖尿病肾病早期诊断中的价值

Diagnosis value of urinary retinol binding protein and urinary Alpha-1 acid glycoprotein in early stage of diabetic nephropathies

目的探讨尿视黄醇结合蛋白(RBP)及尿α1酸性糖蛋白(AAG)在糖尿病肾病早期诊断中的价值。方法选取本院确诊的2型糖尿病肾病患者120例为研究对象,根据24 h尿微量白蛋白结果,≤300 mg/24 h的68例患者为微量白蛋白组(微量组),>300 mg/24 h的52例患者为大量白蛋白尿组(大量组)。选取健康体检者40例作为对照组。分别检测其尿微量白蛋白(m Alb)、尿RBP及尿AAG。结果微量组及大量组患者尿RBP和尿AAG指标均高于对照组(P<0.01);大量组患者RBP和尿AAG指标均高于微量组(P<0.01)。结论尿RBP及尿AAG可作为糖尿病肾病的检测指标,其结果有助于糖尿病肾病的早期诊断。

Objective To investigate the diagnosis value of urinary retinol binding protein（RBP） and urinary Alpha-1 acid glycoprotein （AAG） in early stage of diabetic nephropathies. Methods One hundred and twenty patients who were examined with type 2 diabetes mellitus were admitted. According to the results of 24 h urine microalbumin, these patients were divided into micro-albumin group（ ≤300 mg/24 h） and macro albumin group（ 〉300 mg/24 h） ;forty health physical examination personnel were selected at same period as control group. The level of urinary microalbumin（ mAlb）, urinary retinol binding protein（RBP） and urinary Alpha-1 acid gly- coprotein （AAG） were analysed. Results The level of nrinary-RBP, urinary-AAG of micro-albumin and macro-albuminuria group had a significantly lower than those of control group （ P 〈0.01 ） ; The level of urinary-RBP and urinary-AAG of macro-albumin group had a significantly higher than those of micro-albumin group （ P 〈 0. 01 ）. Conclusion Urinary-RBP, urinary-AAG can be used as the index of diabetic nepbropathy, the result is helpful to the early diagnosis of diabetic nephropathy.