急性缺血性脑卒中患者血浆PMP及EMP含量与预后的相关性

Relationship between circulating platelets microparticles and endothelial microparticls and prognosis in patients with acute ischemic stroke

目的探讨急性缺血性脑卒中(AIS)患者血浆中血小板微粒体(PMP)和内皮细胞微粒体(EMP)水平与其预后的关系。方法以德州市人民医院神经内科2013年3月至2015年6月收治的56例AIS患者(AIS组)和40例体检者(对照组)为研究对象。对所有研究对象进行问卷调查并抽取5 m L静脉血,采用流式细胞仪检测PMP和EMP含量。对AIS组进行入院和出院NIHSS评分,据此将AIS组分为预后不良和预后良好两类。采用Logistic回归分析探讨影响AIS预后的危险因素。结果 AIS组PMP和EMP水平显著高于对照组(P<0.05)。AIS组中预后良好患者的PMP和EMP水平显著低于预后不良的患者(P<0.05)。Logistic回归分析发现,糖尿病、高血压、PMP和EMP水平是影响AIS患者预后的独立预测因子。结论血浆PMP和EMP水平可能作为临床上评估AIS预后的指标。

Objective To explore the relationship between circulating platelets microparticles（ PMP） and endothelial microparticls（ EMP） and prognosis in patients with acute ischemic stroke（ AIS）. Methods Fifty-six patients with AIS（ AIS groups） hospitalized from March,2013 to June,2015 and 40 people who took health examination in Dezhou People＇s Hospital were selected（ Control group）,and all subjects were investigated to explore the risk factors of prognosis. Venous blood（ 5 mL） was extracted from each subject. Flowcytometry was used to detect the levels of PMP and EMP. Patients in AIS group were evaluated by the National Institutes of Health Stroke Scale（ NIHSS） in admission and discharge,and were classified into two types,poor prognosis and favorable prognosis,according to the scores. Risk factors that affected prognosis were investigated by the Logistical regression analysis. Results The levels of PMP and EMP in AIS group were significantly higher than those in Control group（ P〈0. 05）. The levels of PMP and EMP in patients with favorable prognosis were significantly higher than those with poor prognosis（ P〈0. 05）. According to Logistical regression analysis,hypertension,diabetes and levels of circulating PMP and EMP were independent risk factors for the prognosis of AIS patients. Conclusion Circulating PMP and EMP levels are associated with AIS,which play important roles in the prognosis of AIS patients.